|
Keloid
|
0.440 |
Biomarker
|
disease |
BEFREE |
The data we provided herein enrich the knowledge regarding the molecular mechanism of NEDD4 involved in the pathogenesis of keloid, defining a new regulatory role for STAT3 in keloid.
|
31451218 |
2019 |
|
Keloid
|
0.440 |
Biomarker
|
disease |
BEFREE |
These results suggest that NEDD4 TV3 is a potential diagnostic marker and therapeutic target for chronic skin diseases, including keloid.
|
30273597 |
2019 |
|
Keloid
|
0.440 |
Biomarker
|
disease |
BEFREE |
Finally, although NEDD4-1 has previously been identified as a factor in keloid susceptibility, and the protein for which it encodes is known to degrade PTEN by catalyzing its polyubiquitylation, the detailed mechanism behind its involvement in keloid formation needs to be further studied.
|
26535660 |
2015 |
|
Keloid
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
We found three SNPs in two regions showed significant association with keloid in the Chinese Han population: 1q41 (rs873549, P = 3.03×10(-33), OR = 2.05, 95% CI: 1.82-2.31 and rs1442440, P = 9.85×10(-18), OR = 0.56, 95% CI: 0.49-0.64, respectively) and 15q21.3 (rs2271289 located in NEDD4, P = 1.02×10(-11), OR = 0.66, 95% CI: 0.58-0.74).
|
23667473 |
2013 |
|
Keloid
|
0.440 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
|
20711176 |
2010 |
|
Keloid
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
|
20711176 |
2010 |
|
Keloid
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
|
20711176 |
2010 |
|
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
|
31456194 |
2019 |
|
Malignant neoplasm of breast
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
NEDD4-1 and NRDP1 expression were not associated with clinical outcomes in HER2-amplified breast cancer, irrespective of adjuvant trastuzumab therapy.
|
30367623 |
2018 |
|
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.
|
29851245 |
2018 |
|
Malignant neoplasm of breast
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether NEDD4 contributes to low PTEN levels in human breast cancer, we analyzed the expression of these proteins by immunohistochemistry across a large Swedish cohort of breast tumor specimens, and their transcript expression levels by microarrays.
|
26276352 |
2016 |
|
Malignant neoplasm of breast
|
0.350 |
Biomarker
|
disease |
BEFREE |
Furthermore, the expression levels of p34(SEI-1) and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer.
|
23970032 |
2013 |
|
Malignant neoplasm of breast
|
0.350 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
In searching for candidate genes for bipolar disorder on chromosome 18q21, a novel gene homologous to NEDD4 (Neural precursor cells expressed developmentally down-regulated) was identified using exon trapping and cDNA cloning.
|
11840194 |
2001 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In searching for candidate genes for bipolar disorder on chromosome 18q21, a novel gene homologous to NEDD4 (Neural precursor cells expressed developmentally down-regulated) was identified using exon trapping and cDNA cloning.
|
11840194 |
2001 |
|
Toxic Epidermal Necrolysis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
|
25811541 |
2015 |
|
Stevens-Johnson Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
|
25811541 |
2015 |
|
Drug-Induced Stevens Johnson Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
|
25811541 |
2015 |
|
Mycoplasma-Induced Stevens-Johnson Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
|
25811541 |
2015 |
|
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
|
25811541 |
2015 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Muscular Atrophy
|
0.200 |
Biomarker
|
phenotype |
RGD |
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.
|
19125695 |
2009 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Neural precursor cell-expressed developmentally downregulated gene 4-1 (NEDD4-1, also known as NEDD4) is a founding member of the NEDD4 family of E3 ligases and is involved in the proliferation, migration, invasion and drug sensitivity of cancer cells.
|
31390487 |
2020 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Among E3s, neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) has been shown to play a critical role in modulating the proliferation, migration, and invasion of cancer cells and the sensitivity of cancer cells to anticancer therapies via regulating multiple substrates.
|
31787758 |
2019 |