|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
|
21376321 |
2011 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in gene locations of CDKN2B-AS1 (Rs2383206), HDAC9 (Rs11984041), NINJ2 (Rs12425791), NAA25 (Rs17696736) are not risk factors for ischemic stroke in childhood.
|
30656483 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants.
|
24959832 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009.
|
25096477 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population.
|
31372770 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, we carried out a meta-analysis to identify the association between nerve injury-induced protein 2 (NINJ2) gene polymorphisms (rs11833579 and rs12425791) and the risk of IS.
|
31258083 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant allelic association was identified between NINJ2 gene rs11833579 (P = 0.008), protein kinase C η gene rs2230501 (P = 0.039) and IS.
|
24664524 |
2014 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the underlying mechanisms of NINJ2 in ischemic stroke or atherosclerosis are still unknown.
|
28431986 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
|
22297388 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk.
|
22795341 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we report a new genetic variant, rs10849373, located in the first intron of the NINJ2 gene, conferring risk of ischemic stroke in Chinese Han subjects.
|
21722921 |
2011 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The global test for the association between NINJ2 haplotypes and AD was significant (p = 0.03).
|
21674003 |
2011 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Borderline Personality Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients.
|
24367640 |
2013 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, NINJ2-silenced or NINJ2-knockout CRC xenografts grew significantly slower than the control xenografts.
|
31597121 |
2019 |
|
Presenile dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
|
21674003 |
2011 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, ectopic overexpression of Ninj2 promoted glioma cell progression <i>in vitro</i>.
|
31794427 |
2019 |
|
Herpes NOS
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The following nerve injury testing was performed on all of the patients including: the numerical rating scale (NRS) test, quantitative sensory testing (QST), and the investigation of serum NINJ2 levels on the 7th day of AHN; in addition, all of the patients repeated all of the items at 6 months after herpes.
|
29069724 |
2017 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we genotyped two NINJ2 single nucleotide polymorphisms (SNPs) namely rs11833579 and rs3809263 in a population of Iranian patients with MS as well as healthy individuals.
|
31292852 |
2019 |
|
Dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
|
21674003 |
2011 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Two of the genes that showed both methylation and expression differences, NINJ2 and SLFN12, have not previously been implicated in MS. SLFN12 is a particularly compelling target of further research, as this gene is known to be down-regulated during T cell activation and up-regulated by type I interferons (IFNs), which are used to treat MS.
|
30379917 |
2018 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |