|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The global test for the association between NINJ2 haplotypes and AD was significant (p = 0.03).
|
21674003 |
2011 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Borderline Personality Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients.
|
24367640 |
2013 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk.
|
22795341 |
2012 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians.
|
21376321 |
2011 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Other loci associated with stroke in previous studies, including NINJ2, were not confirmed.
|
26708676 |
2016 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In 2009, a genome-wide association study (GWAS) identified two variants (rs12425791 and rs11833579) near NINJ2 gene that confer susceptibility to stroke in Caucasian populations.
|
26312640 |
2016 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Further validation of the functionality of the NINJ2 rs3809263 G > A polymorphism and its association with risk of LAA stroke in other ethnic populations is warranted.
|
26687183 |
2016 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Two intergenic single-nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 were associated with stroke (P<5x10(-8)).
|
19369658 |
2009 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Among the acknowledged risk factors of stroke are the single nucleotide polymorphisms (SNPs) near Ninjurin 2 (NINJ2) gene which encodes a surface adhesion protein.
|
31372770 |
2019 |
|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Previous genetic studies suggested that variants in NINJ2 (encode ninjurin2) confer risk to ischemic stroke or large artery atherosclerotic stroke.
|
28431986 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, NINJ2-silenced or NINJ2-knockout CRC xenografts grew significantly slower than the control xenografts.
|
31597121 |
2019 |
|
Dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
|
21674003 |
2011 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, ectopic overexpression of Ninj2 promoted glioma cell progression <i>in vitro</i>.
|
31794427 |
2019 |
|
Herpes NOS
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The following nerve injury testing was performed on all of the patients including: the numerical rating scale (NRS) test, quantitative sensory testing (QST), and the investigation of serum NINJ2 levels on the 7th day of AHN; in addition, all of the patients repeated all of the items at 6 months after herpes.
|
29069724 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
|
21376321 |
2011 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in gene locations of CDKN2B-AS1 (Rs2383206), HDAC9 (Rs11984041), NINJ2 (Rs12425791), NAA25 (Rs17696736) are not risk factors for ischemic stroke in childhood.
|
30656483 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants.
|
24959832 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009.
|
25096477 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the present case-control study supports the role of NINJ2 as a risk locus for ischemic stroke in Iranian population.
|
31372770 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, we carried out a meta-analysis to identify the association between nerve injury-induced protein 2 (NINJ2) gene polymorphisms (rs11833579 and rs12425791) and the risk of IS.
|
31258083 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant allelic association was identified between NINJ2 gene rs11833579 (P = 0.008), protein kinase C η gene rs2230501 (P = 0.039) and IS.
|
24664524 |
2014 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the underlying mechanisms of NINJ2 in ischemic stroke or atherosclerosis are still unknown.
|
28431986 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
|
22297388 |
2012 |