|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The biological relevance of the novel phosphorylation identified herein is suggested by the direct correlation of in vivo Nm23 acid-stable phosphorylation levels, but not Nm23 NDPK activity, with suppression of tumor metastatic potential among control and nm23-1 transfected murine melanoma cells.
|
8245015 |
1993 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A novel mutation of the nm23 gene was found in one case of stage III serous carcinoma without lymph model metastases.
|
7669582 |
1995 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduced expression of nm23 RNAs/proteins has been associated previously with high tumor metastatic potential.
|
8384356 |
1993 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Within histologic groups, we found no correlation between nm23 expression and nodal involvement of distant metastases.
|
8273382 |
1994 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
It was proposed that nm23 may function as a suppressor gene for tumour metastasis.
|
7931824 |
1994 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Apart from a housekeeping function, NM23 proteins are involved in the regulation of many cellular processes as well as in tumor metastasis, but their functions in epidermal homeostasis and repair are largely unknown.
|
16862176 |
2007 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
It is thought that nm23 protein may play a specific biological role in suppressing tumor metastasis.
|
10523705 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
One of the genes involved in tumor metastasis is NM23.
|
12405283 |
2002 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NME1 (also known as NM23-H1) was the first identified tumor metastasis suppressor, which has been reported to link with genomic stability maintenance and cancer.
|
30875636 |
2019 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nuclear nm23 staining correlated to decreased risk for metastatic disease and distant metastases per se (P < 0.01).
|
10999844 |
2000 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.
|
29863788 |
2018 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduced RNA and/or protein levels corresponding to the murine nm23-1 and human nm23-H1 complementary DNA clones have been correlated with high tumor metastatic potential in several rodent model systems and human breast carcinomas.
|
1988104 |
1991 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have analyzed expression of nm23 polypeptide in acquired melanocytic nevi (n = 19), dysplastic nevi (n = 19), malignant melanomas (n = 22) and metastases of malignant melanomas (n = 47) in situ.
|
9094461 |
1997 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduced expression of nm23 has been associated with increased metastases and decreased survival in a variety of malignancies.
|
7776445 |
1995 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Whereas most genetic alterations of primary tumours remain unchanged in metastases, expression of the cell adhesion molecule Ep-CAM and of nm23 is more frequently reduced than increased in metastases, compared with their primary tumours, suggesting relevance to the process of metastasis.
|
11439361 |
2001 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
When studying Bgl II RFLPs, allelic losses of the nm23 gene were found in 3/12 (25%) informative tumors, and all 3 had lymph node and/or distant metastases.
|
9334657 |
1997 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor metastasis is an essential aspect of lung cancer progression. nm23-H1 is a metastasis suppressor gene.
|
18440302 |
2008 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The EBV critical latent antigens EBNA1 and EBNA3C interact with Nm23-H1, a known suppressor of cell migration and tumor metastasis.
|
17634231 |
2007 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23.
|
12145286 |
2002 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The product of Nm23 gene has been proposed as a candidate tumour metastasis suppressor protein.
|
8394105 |
1993 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Because of NDPK-A's dichotomous role in tumor metastasis as both a suppressor and a promoter, tumor genome/exome profiles are necessary to identify the molecular drivers of metastasis in the NDPK-A network for developing tumor-specific therapies.
|
28991262 |
2018 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our present data indicate that expression of nm23-H1 by a tumor could be altered during the different steps in metastases, suggesting that nm23-H1 may act as a molecular switch between the free-floating and adherent states of cancer cells.
|
11675153 |
2001 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduced NM23-H1, defined as intermediate and low levels of expression, tended to have a higher risk of tumor metastasis (P = 0.06) or poor longtime survival (P = 0.07).
|
10999750 |
2000 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nm23 expression was significantly reduced and Ki67 antigen expression increased in primary tumours with either lymph node or organ metastases in comparison to tumours without metastases.
|
16277028 |
2005 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings indicate that, in contrast to a proposed role for nm23-H1 as a tumor metastasis suppressor, increased p19/nm23 protein in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors.
|
2056128 |
1991 |