|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of NM-23, a reported tumor metastasis suppressor gene, was found only in leiomyosarcomas (5 of 9, or 56%), and 4 of 5 (80%) of these were the only cases that demonstrated distant metastases (P = 0.04).
|
16330948 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrated that nm23-H1 can suppress the mobility and metastatic capacity of cancer cells and the molecular mechanism by which nm23-H1 suppresses tumor metastasis may be via increasing the expression of metastasis-related genes such as beta-Catenin, E-Cadherin and TIMP-1 and decreasing the expression of MMP-2, CD44V6 and VEGF.
|
17167724 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential.
|
16739125 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
To further explore the tumor metastasis suppressor function of nm-23 in HNSCC, we studied high-stage laryngeal carcinomas, tumors with and without cervical lymph node metastasis for nm-23 protein expression and loss of heterozygosity of the gene locus.
|
16531762 |
2006 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nm23 expression was significantly reduced and Ki67 antigen expression increased in primary tumours with either lymph node or organ metastases in comparison to tumours without metastases.
|
16277028 |
2005 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A more than twofold decreased expression of nm23-H1 mRNA was reported in 28/52 (54%) of the carcinomas and was positively associated with the presence of nodal metastases and Astler-Coller stages B1 and B2 in 29% and 35% of the SCRCs, respectively.
|
12684753 |
2003 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, our results implicated the differential regulation of Nm23-H1 by p53 in different cell types as an important component in the molecular mechanisms of tumor metastasis.
|
12669312 |
2003 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
One of the genes involved in tumor metastasis is NM23.
|
12405283 |
2002 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23.
|
12145286 |
2002 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene.
|
11796500 |
2002 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Low nm23 expression is predictive of distal metastases and appears to be a risk factor that is independent of the presence or absence of positive axillary nodes at diagnosis.
|
11179491 |
2001 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, nm-23-H1 immunoreactivity was more specific but less sensitive than AMES score to predict metastases.
|
11502841 |
2001 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumor suppressor gene MTS1/p16 (cyclin-dependent kinase-4 inhibitor) and a putative tumor metastasis suppressor gene nm23 (nucleoside diphosphate A kinase) have been identified in a variety of human tumors but have not been well studied in mesenchymal neoplasms.
|
11223831 |
2001 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Whereas most genetic alterations of primary tumours remain unchanged in metastases, expression of the cell adhesion molecule Ep-CAM and of nm23 is more frequently reduced than increased in metastases, compared with their primary tumours, suggesting relevance to the process of metastasis.
|
11439361 |
2001 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our present data indicate that expression of nm23-H1 by a tumor could be altered during the different steps in metastases, suggesting that nm23-H1 may act as a molecular switch between the free-floating and adherent states of cancer cells.
|
11675153 |
2001 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nuclear nm23 staining correlated to decreased risk for metastatic disease and distant metastases per se (P < 0.01).
|
10999844 |
2000 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reduced NM23-H1, defined as intermediate and low levels of expression, tended to have a higher risk of tumor metastasis (P = 0.06) or poor longtime survival (P = 0.07).
|
10999750 |
2000 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, it is possible that T3 promotes tumor metastasis by inducing down-regulation of Nm23-H1 expression.
|
10875256 |
2000 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
This interaction may play important roles in the effects of Rad on glucose metabolism and the effects of nm23 on tumor metastasis and developmental regulation.
|
10611312 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
It is thought that nm23 protein may play a specific biological role in suppressing tumor metastasis.
|
10523705 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The NM23-H1 positive group showed lower frequency of lymph node metastasis, and a better grading than the NM23-H1 negative group supporting the role of NM23-H1 as metastasis suppressor factor which may be useful for predicting tumor metastasis in OSCC.
|
10373649 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The nm23 gene has been proposed as a candidate tumor metastasis suppressor in some human cancers.
|
9663428 |
1998 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have analyzed expression of nm23 polypeptide in acquired melanocytic nevi (n = 19), dysplastic nevi (n = 19), malignant melanomas (n = 22) and metastases of malignant melanomas (n = 47) in situ.
|
9094461 |
1997 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
When studying Bgl II RFLPs, allelic losses of the nm23 gene were found in 3/12 (25%) informative tumors, and all 3 had lymph node and/or distant metastases.
|
9334657 |
1997 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since the discovery of nm23 (nonmetastatic) by Steeg et al. in 1988, a number of tumor cohort studies have shown an inverse relationship between the levels of expression of the nm23-H1 protein and disease aggressiveness and tumor metastatic potential.
|
9070493 |
1997 |