NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1861457
Disease: PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY
PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY 		0.010 AlteredExpression disease BEFREE Number of inflammatory focis and neutrophils as well as iNOS protein levels were higher in livers of PERM-treated rats than in those of PERM+ERW and control rats. 31600256 2019
CUI: C1868684
Disease: EAR, PATELLA, SHORT STATURE SYNDROME
EAR, PATELLA, SHORT STATURE SYNDROME 		0.010 AlteredExpression disease BEFREE In addition, expression of inducible NO synthase (iNOS) and IκB‑α degradation were enhanced in PH‑EPS‑treated cells. 31638207 2019
CUI: C1955760
Disease: Idiopathic normal pressure hydrocephalus (INPH)
Idiopathic normal pressure hydrocephalus (INPH) 		0.010 Biomarker disease BEFREE The relative volume of SHM was significantly larger in the iNPH-NOS group than in the iNPH-AOS group, but there were no significant differences in the relative volumes of VS and SF between these groups. 30950145 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.010 Biomarker disease BEFREE Dietary nitrate fuels a nitrate-nitrite-NO signaling pathway, which prevented many features of metabolic syndrome and liver steatosis that developed in mice fed a high-fat diet, with or without combination with an inhibitor of NOS (l-NAME). 30559212 2019
CUI: C2732618
Disease: Sessile Serrated Adenoma/Polyp
Sessile Serrated Adenoma/Polyp 		0.010 GeneticVariation disease BEFREE A total of 22 mucosal lesions were revealed in 8 CRC patients comprising conventional IBD-associated dysplasia (4 lesions), PPLs as serrated change/dysplasia NOS (11 lesions), villous hypermucinous change (5 lesions), and two true serrated lesions (one sessile serrated adenoma and one traditional serrated adenoma). 30679085 2019
CUI: C3668948
Disease: Circling behavior
Circling behavior 		0.010 AlteredExpression phenotype BEFREE To do so, we microinjected saline solution or QUIN in the striatum of wild-type (nNOS +/+), heterozygote (nNOS+/-), and knock-out (nNOS-/-) mice, and measured circling behavior, GABA content levels, oxidative stress, and NOS expression and activity. 30523577 2019
CUI: C4285066
Disease: Double-Hit Lymphoma
Double-Hit Lymphoma 		0.010 Biomarker disease BEFREE Here, we performed three methods including immunohistochemistry (IHC) (clone SP263 and SP142), RNAscope, and fluorescence in situ hybridization (FISH) to evaluate PD-L1 status on a cohort of DLBCL including 94 of DLBCL-NOS, 25 of primary mediastinal large B-cell lymphoma (PMBCL) and 7 of double-hit lymphoma (DHL). 31150165 2019
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.010 Biomarker group BEFREE Targeting nitric oxide synthase 2 and associated nitrosative stress using naturally occurring phytochemicals is a potential approach to preventing birth defects in diabetic pregnancies. 29733843 2018
CUI: C0003857
Disease: Congenital arteriovenous malformation
Congenital arteriovenous malformation 		0.010 Biomarker disease BEFREE ABBREVIATIONS AVM = arteriovenous malformation; CI = confidence interval; NOS = Newcastle-Ottawa Scale; OR = odds ratio; SM = Spetzler-Martin. 30544349 2018
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy 		0.010 Biomarker disease BEFREE Patient A underwent resection of a anaplastic astrocytoma NOS associated with the left speech SMA, experienced SMA syndrome related mutism postoperatively, but experienced full recovery 14 months later. 29783125 2018
CUI: C0026884
Disease: Mutism
Mutism 		0.010 GeneticVariation phenotype BEFREE Patient A underwent resection of a anaplastic astrocytoma NOS associated with the left speech SMA, experienced SMA syndrome related mutism postoperatively, but experienced full recovery 14 months later. 29783125 2018
CUI: C0027707
Disease: Nephritis, Interstitial
Nephritis, Interstitial 		0.010 Biomarker disease BEFREE This is the first reported case of rapidly progressive renal failure caused by perivascular tubulointerstitial nephritis with the direct invasion of PTCL-NOS. 30409117 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.010 Biomarker phenotype BEFREE Can modulation of inducible NO synthase reduce pain behaviour and pro-inflammatory cytokine signalling in a rat model of neuropathic pain? 29441689 2018
CUI: C0029118
Disease: Opportunistic Infections
Opportunistic Infections 		0.010 AlteredExpression group BEFREE Using nitric oxide synthase-deficient mice, we found that Nos2 was required for increases in IL-10, MCP-1, and HA following injury but not release of dsDNA, CXCL1 expression, early neutrophilia, or susceptibility to opportunistic infection. 29368547 2018
CUI: C0038034
Disease: Sporotrichosis
Sporotrichosis 		0.010 Biomarker disease BEFREE LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. 29440688 2018
CUI: C0040953
Disease: Trichotillomania
Trichotillomania 		0.010 Biomarker disease BEFREE The expression of BB was attenuated by repeated treatment with clomipramine, a clinically approved drug to treat TTM in humans, or memantine, an antagonist of NMDA receptors, as well as partial rescue of NOS2 expression in haploinsufficient animals. 29682419 2018
CUI: C0041349
Disease: Nephritis, Tubulointerstitial
Nephritis, Tubulointerstitial 		0.010 Biomarker disease BEFREE This is the first reported case of rapidly progressive renal failure caused by perivascular tubulointerstitial nephritis with the direct invasion of PTCL-NOS. 30409117 2018
CUI: C0042025
Disease: Urinary Stress Incontinence
Urinary Stress Incontinence 		0.010 Biomarker disease BEFREE Altough our findings indicate important results, well designed further studies are needed to comprehend the role of NOS pathways better in SUI pathophysiology. 29900523 2018
CUI: C0042164
Disease: Uveitis
Uveitis 		0.010 Biomarker disease BEFREE In this study, we evaluated the preventive and curative effects of ethanolic extract of Propolis (EEP) during α-Tropomyosin-induced uveitis in an experimental model using Wistar rats, through the regulation of inducible nitric oxide synthase (NOS2) and arginase-1. 29752572 2018
CUI: C0085541
Disease: Epilepsy, Frontal Lobe
Epilepsy, Frontal Lobe 		0.010 Biomarker disease BEFREE Our study describes the overexpression of inflammatory-related genes and NOS isozymes in OB from FLE patients. 30366204 2018
CUI: C0086543
Disease: Cataract
Cataract 		0.010 Biomarker disease BEFREE The findings demonstrated that NO donor exacerbates and NOS inhibitor alleviates the cataract formation in hypertensive condition. 30015520 2018
CUI: C0220810
Disease: Congenital defects
Congenital defects 		0.010 Biomarker group BEFREE Targeting nitric oxide synthase 2 and associated nitrosative stress using naturally occurring phytochemicals is a potential approach to preventing birth defects in diabetic pregnancies. 29733843 2018
CUI: C0233401
Disease: Psychiatric symptom
Psychiatric symptom 		0.010 Biomarker phenotype BEFREE PDD-NOS, psychotic features and executive function deficits in a boy with proximal 22q11.2 microduplication: Evolution of the psychiatric symptom profile from childhood to adolescence. 29307791 2018
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.010 Biomarker group BEFREE In contrast, 7-nitroindazole decreased c-Fos-positive NOS neurons and attenuated caffeine-induced increase in c-Fos-positive NOS neurons. 30504686 2018
CUI: C0259783
Disease: mixed gliomas
mixed gliomas 		0.010 Biomarker disease BEFREE The most common initial ICD-O-3 pathology was oligodendroglioma, NOS; astrocytoma, NOS; astrocytoma, anaplastic; and mixed glioma. 30279958 2018