|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
|
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Reduced eNOS activity could mediate an increased stroke risk through hypertension or independent of hypertension through abnormal vasomotor responses, promoting atherogenesis, or increased platelet adhesion and aggregation.
|
9731617 |
1998 |
|
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
LV endomyocardial expression of NOS3 was linearly correlated with LV stroke volume (P=0.01; r=0.53) and LV stroke work (P=0.01; r=0.52).
|
10368118 |
1999 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
|
10430441 |
1999 |
|
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The intensity of NOS2 and NOS3 gene expression observed in athlete's heart was similar to dilated cardiomyopathy with low LV diastolic stiffness-modulus and preserved LV stroke work.
|
12123766 |
2002 |
|
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
|
12464678 |
2002 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.
|
15595935 |
2005 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility.
|
16100023 |
2005 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
These results demonstrate that bortezomib promotes eNOS dependent vascular protection, and reduces NF-kappaB dependent vascular disruption, all of which may contribute to neuroprotection after stroke.
|
16543976 |
2006 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We sought to determine whether cigarette smoking modified the association between NOS3 polymorphisms and risk of coronary heart disease or stroke.
|
17108813 |
2006 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
We sought to determine whether cigarette smoking modified the association between NOS3 polymorphisms and risk of coronary heart disease or stroke.
|
17108813 |
2006 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset.
|
17165044 |
2007 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset.
|
17165044 |
2007 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the presence of other coexisting risk factors the AGTR1 A(1166)C but not the NOS3 G(894)T polymorphism increased the risk of stroke.
|
17586411 |
2007 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
RGD |
Results demonstrate that the eNOS protein within the medulla may play a significant role in mediating cardiovascular responses during static exercise in pathophysiological conditions, such as stroke.
|
18234158 |
2008 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese population.
|
18396156 |
2008 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.
|
18602910 |
2008 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
We aimed to study whether variations in vasoregulatory endothelial nitric oxide synthase (eNOS 4a/b) and tissue-injury-associated inducible nitric oxide synthase (iNOS R5/4) genes and smoking might explain gender differences in long-term survival after stroke.
|
18648197 |
2008 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to study whether variations in vasoregulatory endothelial nitric oxide synthase (eNOS 4a/b) and tissue-injury-associated inducible nitric oxide synthase (iNOS R5/4) genes and smoking might explain gender differences in long-term survival after stroke.
|
18648197 |
2008 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/ polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [ID], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls.
|
19372095 |
2009 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Only 1 of the tested SNP (NOS3 rs3918166) was associated with both migraine and stroke.
|
19661472 |
2009 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We tested a single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (NOS3) gene at codon 298 (single-nucleotide polymorphism rs1799983; p.Asp298Glu) in a cohort of 355 older (>75 years) stroke survivors, who had detailed cognitive assessments from 3 months poststroke, i.e., baseline when the patients were free of dementia and subsequently at annual intervals.
|
20691505 |
2011 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, we examined the possible association of eNOS G894T variation with stroke severity and functional outcome.
|
22004707 |
2011 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results highlight NOS1 as a susceptibility factor for stroke, but do not corroborate previous NOS3 association findings with stroke risk. nNOS is known to play a major role in atherosclerosis development and in blood flow regulation, and it is plausible that its influence in stroke may be mediated through these two main clinical risk factors.
|
22153699 |
2012 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We observed significant associations with NOS3 variants and CHD and heart failure and significant pharmacogenetic effects for stroke and all cause mortality.
|
22470539 |
2012 |