Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, the activity of the eNOS enzyme and the metabolism of major NO metabolite S-nitrosoglutathione (GSNO) are dysregulated after stroke, causing endothelial dysfunction.
|
31680031 |
2019 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We assessed the effects of glyceryl trinitrate (GTN) on hemodynamic parameters and these on outcome in participants in the ENOS trial (Efficacy of Nitric Oxide in Stroke).
|
30626285 |
2019 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The purpose of the present study was to assess the specific role of eNOS in cognitive performance after stroke.
|
29406402 |
2018 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We identified an exonic polymorphism in NOS3 (rs1799983, rs1799983" genes_norm="4846">p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04-1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03-1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03-1.07) at genome-wide significance for stroke.
|
30383316 |
2018 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide meta-analysis identifies 3 novel loci associated with stroke.
|
30383316 |
2018 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The phosphoinositide 3‑kinase membrane translocation of cerebral stroke rats pretreated with CPT at various concentrations were measured, as well as the phosphorylation of protein kinase B (AKT) and endothelial nitric oxide synthase (eNOS).
|
29152647 |
2017 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A tendency toward an increased LAA stroke risk was significant in carriers with the eNOS Glu298Asp variant in conjunction with the G14713 A and T29107A polymorphisms of the Cav-1 (aOR = 2.03, P-trend = 0.002).
|
28346478 |
2017 |
Cerebrovascular accident
|
0.400 |
Therapeutic
|
group |
RGD |
The phosphoinositide 3‑kinase membrane translocation of cerebral stroke rats pretreated with CPT at various concentrations were measured, as well as the phosphorylation of protein kinase B (AKT) and endothelial nitric oxide synthase (eNOS).
|
29152647 |
2017 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MatInspector) were applied to investigate the main variant consequences.Variants in vascular adhesion molecule-1 (VCAM1) gene promoter and endothelial nitric oxide synthase (NOS3) gene were significantly associated with higher degree of hemolysis and stroke events.
|
27814292 |
2016 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Studies from the different ethnic regions of world have reported variable results on association of Apolioprotein E (APOE), Methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen and Phosphodiesterase 4D (PDE4D) gene in stroke.
|
24090469 |
2013 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We observed significant associations with NOS3 variants and CHD and heart failure and significant pharmacogenetic effects for stroke and all cause mortality.
|
22470539 |
2012 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results highlight NOS1 as a susceptibility factor for stroke, but do not corroborate previous NOS3 association findings with stroke risk. nNOS is known to play a major role in atherosclerosis development and in blood flow regulation, and it is plausible that its influence in stroke may be mediated through these two main clinical risk factors.
|
22153699 |
2012 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present study was carried out with an aim to evaluate the association between the genetic variants of lipoprotein lipase gene [HindIII (+/+)/HindIII (-/-)], multiple drug resistance gene (C3435T) and endothelial nitric oxide synthase gene (4a/4b) with clinical outcome including an increased risk of recurrent stroke or death in ischemic stroke patients on atorvastatin therapy.
|
22810051 |
2012 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, we examined the possible association of eNOS G894T variation with stroke severity and functional outcome.
|
22004707 |
2011 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We tested a single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (NOS3) gene at codon 298 (single-nucleotide polymorphism rs1799983; p.Asp298Glu) in a cohort of 355 older (>75 years) stroke survivors, who had detailed cognitive assessments from 3 months poststroke, i.e., baseline when the patients were free of dementia and subsequently at annual intervals.
|
20691505 |
2011 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Only 1 of the tested SNP (NOS3 rs3918166) was associated with both migraine and stroke.
|
19661472 |
2009 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/ polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [ID], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls.
|
19372095 |
2009 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
We aimed to study whether variations in vasoregulatory endothelial nitric oxide synthase (eNOS 4a/b) and tissue-injury-associated inducible nitric oxide synthase (iNOS R5/4) genes and smoking might explain gender differences in long-term survival after stroke.
|
18648197 |
2008 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.
|
18602910 |
2008 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
RGD |
Results demonstrate that the eNOS protein within the medulla may play a significant role in mediating cardiovascular responses during static exercise in pathophysiological conditions, such as stroke.
|
18234158 |
2008 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese population.
|
18396156 |
2008 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to study whether variations in vasoregulatory endothelial nitric oxide synthase (eNOS 4a/b) and tissue-injury-associated inducible nitric oxide synthase (iNOS R5/4) genes and smoking might explain gender differences in long-term survival after stroke.
|
18648197 |
2008 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset.
|
17165044 |
2007 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the presence of other coexisting risk factors the AGTR1 A(1166)C but not the NOS3 G(894)T polymorphism increased the risk of stroke.
|
17586411 |
2007 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset.
|
17165044 |
2007 |