NTF3, neurotrophin 3, 4908

N. diseases: 38; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease CTD_human Variations in the NT3 gene increase the risk of SZ. 18572319 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker group PSYGENET The gene for neurotrophic tyrosine kinase receptor 3 (NTRK3), the receptor for neurotrophin-3 (trkC) and a key gene in neurotrophin signaling, is located within this region and, given evidence for synaptic plasticity as a mechanism in mood disorders, was considered a prime candidate. 18347002 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 Biomarker disease PSYGENET Our results suggest that the changes in the expression levels of GDNF, ARTN, and NT-3 mRNAs might be state-dependent and associated with the pathophysiology of major depression. 18313696 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Our results suggest that the changes in the expression levels of GDNF, ARTN, and NT-3 mRNAs might be state-dependent and associated with the pathophysiology of major depression. 18313696 2008
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.310 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.310 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.310 Therapeutic group CTD_human Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies. 11779407 2001
CUI: C1384666
Disease: hearing impairment
hearing impairment 		0.300 Therapeutic phenotype CTD_human [Protective effect of adeno-associated virus-mediated neurotrophin-3 on the cochlea of guinea pigs with gentamicin-induced hearing loss]. 18024279 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. 16289943 2006
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.300 Biomarker disease CTD_human Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. 16289943 2006
CUI: C0432416
Disease: Down Syndrome, Partial Trisomy 21
Down Syndrome, Partial Trisomy 21 		0.300 Biomarker disease CTD_human Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. 16289943 2006
CUI: C0432417
Disease: Trisomy 21, Meiotic Nondisjunction
Trisomy 21, Meiotic Nondisjunction 		0.300 Biomarker disease CTD_human Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. 16289943 2006
CUI: C0751081
Disease: Trisomy 21, Mitotic Nondisjunction
Trisomy 21, Mitotic Nondisjunction 		0.300 Biomarker disease CTD_human Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. 16289943 2006
CUI: C0014549
Disease: Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsy 		0.300 Biomarker disease CTD_human Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. 16023256 2005
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C0751117
Disease: Cryptogenic Tonic-Clonic Epilepsy
Cryptogenic Tonic-Clonic Epilepsy 		0.300 Biomarker disease CTD_human Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. 16023256 2005
CUI: C0751118
Disease: Epilepsy, Tonic-Clonic, Familial
Epilepsy, Tonic-Clonic, Familial 		0.300 Biomarker disease CTD_human Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. 16023256 2005
CUI: C0751119
Disease: Epilepsy, Tonic-Clonic, Symptomatic
Epilepsy, Tonic-Clonic, Symptomatic 		0.300 Biomarker disease CTD_human Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. 16023256 2005
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Therapeutic phenotype CTD_human Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. 15659614 2005
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Therapeutic phenotype CTD_human Continuous infusion is required for suppression of both thermal hyperalgesia and TRPV1 expression, because removal of NT-3 resulted in a prompt reestablishment of the hyperalgesic state and corresponding CCI-associated TRPV1 phenotype. 15659614 2005
CUI: C0271673
Disease: Symmetric Diabetic Proximal Motor Neuropathy
Symmetric Diabetic Proximal Motor Neuropathy 		0.300 Therapeutic disease CTD_human Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies. 11779407 2001
CUI: C0271674
Disease: Asymmetric Diabetic Proximal Motor Neuropathy
Asymmetric Diabetic Proximal Motor Neuropathy 		0.300 Therapeutic disease CTD_human Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies. 11779407 2001
CUI: C0271678
Disease: Diabetic Mononeuropathy
Diabetic Mononeuropathy 		0.300 Therapeutic disease CTD_human Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies. 11779407 2001