|
Autoimmune Chronic Hepatitis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Also, the serum levels of IL-17A and IL-22 were correlated positively with liver injury (ALT/AST), whereas the serum levels of IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH patients.
|
30050955 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats.
|
21227906 |
2011 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In an experimental model of fungal-associated allergic airway inflammation, we demonstrate that IL-1R1 signaling promotes type 1 (IFN-γ, CXCL9, CXCL10) and type 17 (IL-17A, IL-22) responses that were associated with neutrophilic inflammation and increased airway hyperreactivity.
|
31550242 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum IL-22 levels are increased in patients with atopic dermatitis, which commonly precedes asthma in the atopic march.
|
29920352 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-17A, IL-22, aryl hydrocarbon receptor (AhR), and ILC3 was increased in the nasal tissues of smokers with asthma and CRS.
|
30609423 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We show that IL-21 production by T<sub>H</sub>2 and follicular helper T/ex-follicular helper T cells promotes asthma by inhibiting Treg cells.
|
30654048 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In accordance with the fact that lung epithelial cells play a critical role in the pathogenesis of asthma, we and other groups have shown that IL-22 is involved in the regulation of allergic airway inflammation.
|
30424940 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we review the current understanding of the molecular and cellular mechanisms underlying IL-22-mediated regulation of airway inflammation in asthma.
|
29394345 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, there were no correlations between ILC3 frequencies or the expressions of RORC, IL-17A, and IL-22 and asthma severity.
|
30622974 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Employing IL22<sup>Cre</sup>R26R<sup>eYFP</sup> reporter mice, we identified γδ T cells, iNKT cells, CD4 T cells and ILC3s as sources of IL-22 during fungal asthma; however, only iNKT cells were significantly increased after IL-7 administration.
|
29907867 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Peripheral blood neutrophils isolated from asthmatics were stimulated with IL-21, IL-23, and IL-6 cytokines and their ability to produce IL-17A and IL-17F was determined relative to healthy controls.
|
28635548 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that miR-323-3p acts in a negative feedback loop to control the production of IL-22 in IL-22/IL-17-producing T cells and might thus impact the T-cell responses in asthma.
|
27059796 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma.
|
28658556 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies clearly show that not only Th2 cytokines but also other T cell-related cytokines such as IL-17A and IL-22 as well as epithelial cell cytokines such as IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are involved in the pathogenesis of asthma.
|
28658544 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The promotion of protein S-glutathionylation by asthma mediators such as interleukin-22 and platelet-derived growth factor or by knocking down glutaredoxin-1 or thioredoxin activated cell growth signaling.
|
26499037 |
2016 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The PAH-induced IL-22 levels in asthmatic patients were significantly higher than in healthy subjects.
|
25860963 |
2015 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Polyp IL-21 level was significantly associated with polyp size, tissue eosinophilia and asthma comorbidity, and recurrence after surgery (P < 0.05).
|
25495679 |
2015 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-17A poorly enhanced IL-1β or IL-22 gene responses in ASM cells from both subjects with mild asthma and healthy donors.
|
24393021 |
2014 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with IL-17 and IL-22 responses directed against innocuous antigens.
|
24942687 |
2014 |
|
Middle Cerebral Artery Syndrome
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |
|
Middle Cerebral Artery Thrombosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |
|
Middle Cerebral Artery Occlusion
|
0.300 |
Biomarker
|
disease |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |
|
Infarction, Middle Cerebral Artery
|
0.300 |
Biomarker
|
disease |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |
|
Middle Cerebral Artery Embolus
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |
|
Left Middle Cerebral Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.
|
25257527 |
2014 |