|
rs1179251
|
IL22;LOC105369818
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
rs1179251
|
IL22;LOC105369818
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
rs1179251
|
IL22;LOC105369818
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis revealed that rs11</span>79251 was associated with advanced stages, lymph node metastases, and distant metast</span>ases of GC (p < 0.05).
|
25387810 |
2015 |
|
rs1179251
|
IL22;LOC105369818
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis revealed that rs11</span>79251 was associated with advanced stages, lymph node metastases, and distant metast</span>ases of GC (p < 0.05).
|
25387810 |
2015 |
|
rs1179251
|
IL22;LOC105369818
|
Precancerous Conditions
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated gene variants onlyIL10T-819C, IL-8-251, IL-18RAP917997, IL-22 rs1179251, IL1-B-511, IL1-B-3954, IL4R-398 and IL1RN were identified as predictors for premalignant gastric lesions risk.
|
31435167 |
2019 |
|
rs2227473
|
IL22;LOC105369818
|
Tuberculosis of intestines
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele frequency of rs2227473 (<i>P</i> = 0.030, odds ratio = 0.60, 95% confidence interval: 0.37-0.95) showed an abnormal distribution between intestinal tuberculosis and healthy controls.
|
31171891 |
2019 |
|
rs2227473
|
IL22;LOC105369818
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs1179251, rs2227485, rs2227511, and rs2227473 polymorphisms may not be associated with cancer risk.
|
31832882 |
2019 |
|
rs2227473
|
IL22;LOC105369818
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs1179251, rs2227485, rs2227511, and rs2227473 polymorphisms may not be associated with cancer risk.
|
31832882 |
2019 |
|
rs2227485
|
IL22;LOC105369818
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
The results further confirmed our present findings and showed that rs1179251, rs2227485, and rs2227473 were not associated with cancer risk in total or stratified analysis.
|
31832882 |
2019 |
|
rs2227485
|
IL22;LOC105369818
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The results further confirmed our present findings and showed that rs1179251, rs2227485, and rs2227473 were not associated with cancer risk in total or stratified analysis.
|
31832882 |
2019 |
|
rs2227511
|
IL22;LOC105369818
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs1179251, rs2227485, rs2227511, and rs2227473 polymorphisms may not be associated with cancer risk.
|
31832882 |
2019 |
|
rs2227511
|
IL22;LOC105369818
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs1179251, rs2227485, rs2227511, and rs2227473 polymorphisms may not be associated with cancer risk.
|
31832882 |
2019 |
|
rs1179251
|
IL22;LOC105369818
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of IL-22 rs1179251 may be a protective factor for concomitant hypertension and CAD.
|
29981321 |
2018 |
|
rs1179251
|
IL22;LOC105369818
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of IL-22 rs1179251 may be a protective factor for concomitant hypertension and CAD.
|
29981321 |
2018 |
|
rs2227513
|
IL22;LOC105369818
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs2227513 polymorphism might contribute to SLE susceptibility, probably by decreasing the expression of IL-22.
|
29603203 |
2018 |
|
rs1012356
|
IL22;LOC105369818
|
Malaria, Cerebral
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs of IL22, rs1012356 (P = 0.016, OR = 2.12) and rs2227476 (P = 0.007, OR = 2.08) were independently associated with CM in a sample of 115 Nigerian children with CM and 160 controls.
|
28139719 |
2017 |
|
rs1179251
|
IL22;LOC105369818
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype CC in rs1179251 was higher in male HT.
|
28839453 |
2017 |
|
rs1179251
|
IL22;LOC105369818
|
Thyroid associated opthalmopathies
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, genotype CC of rs1179251 and genotype GG of rs11611206 were associated with Graves' ophthalmopathy (GO).
|
28839453 |
2017 |
|
rs1179251
|
IL22;LOC105369818
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
|
28839453 |
2017 |
|
rs2227473
|
IL22;LOC105369818
|
Malaria, Cerebral
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2227473, in linkage disequilibrium with rs2227476, was also associated with CM in the combined cohort for these two populations, (P = 0.004, OR = 1.55).
|
28139719 |
2017 |
|
rs2227476
|
IL22;LOC105369818
|
Malaria, Cerebral
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2227473, in linkage disequilibrium with rs2227476, was also associated with CM in the combined cohort for these two populations, (P = 0.004, OR = 1.55).
|
28139719 |
2017 |
|
rs2227478
|
IL22;LOC105369818
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
|
28839453 |
2017 |
|
rs2227478
|
IL22;LOC105369818
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Alleles C at rs2046068, C at rs2227478, and C at rs1179251 linked to the susceptibility of HT males.
|
28839453 |
2017 |
|
rs1179251
|
IL22;LOC105369818
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggested that IL-18RAP rs917997, IL-32 rs2015620, IL-22 rs1179251, and interactions between these polymorphisms and H. pylori infection</span> were associated with risks of gastric lesions.
|
26358252 |
2016 |
|
rs1179251
|
IL22;LOC105369818
|
Intestinal metaplasia
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, elevated risks of CAG (OR = 2.64, 95 % CI 1.89-3.69), intestinal metaplasia (IM; OR = 5.58, 95 % CI 3.86-8.05), and dysplasia (DYS; OR = 1.64, 95 % CI 1.18-2.26) were observed in subjects with IL-22 rs1179251 CC genotype.
|
26358252 |
2016 |