|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study.
|
17218510 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls.
|
23950976 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.
|
17471297 |
2007 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.
|
19360016 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
INSIG2 plays a role in weight gain and obesity during clozapine treatment.
|
27885961 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis.
|
25607990 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 1,001 white individuals with extreme obesity (BMI >35 kg/m(2)) who underwent a preoperative diet/behavioral weight loss intervention and Roux-en-Y gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in or near the fat mass and obesity-associated (FTO), insulin induced gene 2 (INSIG2), melanocortin 4 receptor (MC4R), and proprotein convertase subtilisin/kexin type 1 (PCSK1) obesity genes.
|
21311511 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 15.1% of participants were overweight or obese at age 16 y.No associations with INSIG2 were found.
|
20007308 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD.
|
20920244 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although INSIG2 polymorphisms do not consistently associate with BMI, the observation of an association with glucose concentration would support a role for this gene in the metabolic complications of obesity.
|
20645959 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rs7566605 was not significantly associated with obesity in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in INSIG2 with both BMI and ABDCIR.
|
20028541 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the single-nucleotide polymorphisms (SNPs) previously reported to be associated with body mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective variant rs2229616 on the melanocortin-4 receptor (MC4R) gene.
|
24518831 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both.
|
18347269 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of insulin-induced gene 2 (INSIG2) variants with obesity has been confirmed in several but not all follow-up studies.
|
22968099 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.
|
19263810 |
2008 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity.
|
27623943 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, we investigated the association of the INSIG2 rs7566605 polymorphism with obesity- and lipid-related traits in Danish and Estonian children (930 boys and 1,073 girls) from the European Youth Heart Study (EYHS), a school-based, cross-sectional study of pre- and early pubertal children.
|
19197262 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene.
|
18270535 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herbert et al.(Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model.
|
17218508 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located approximately 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese.
|
18003761 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a whole-genome scan, a single nucleotide polymorphism (SNP) (rs7566605) upstream of the insulin-induced gene 2 (INSIG2) was shown to influence body mass index and obesity in the Framingham Heart Study, with replication of these results in an additional 4 of 5 studies.
|
20858904 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It has recently been demonstrated that a common single-nucleotide polymorphism (rs7566605) upstream of the transcription start site for the insulin-induced gene 2 is associated with obesity in several European/European origin or African-American cohorts.
|
18070740 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
|
19851442 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One particularly interesting single nucleotide polymorphism (SNP), rs7566605, located 10 kb upstream of INSIG2 was reported to have the strongest association with obesity among 86 604 SNP, while the relationship with dyslipidaemia is uncertain.
|
18570692 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |