|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity.
|
27623943 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
INSIG2 plays a role in weight gain and obesity during clozapine treatment.
|
27885961 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis.
|
25607990 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified a 3-locus interaction on obesity in GMDR analyses (P = 0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2.
|
25028659 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the single-nucleotide polymorphisms (SNPs) previously reported to be associated with body mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective variant rs2229616 on the melanocortin-4 receptor (MC4R) gene.
|
24518831 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.
|
25062423 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites.
|
22695173 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls.
|
23950976 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of insulin-induced gene 2 (INSIG2) variants with obesity has been confirmed in several but not all follow-up studies.
|
22968099 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 1,001 white individuals with extreme obesity (BMI >35 kg/m(2)) who underwent a preoperative diet/behavioral weight loss intervention and Roux-en-Y gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in or near the fat mass and obesity-associated (FTO), insulin induced gene 2 (INSIG2), melanocortin 4 receptor (MC4R), and proprotein convertase subtilisin/kexin type 1 (PCSK1) obesity genes.
|
21311511 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have suggested some candidate genes for obesity- and metabolic-related traits, including the insulin-induced gene (INSIG2), melanocortin 4 receptor gene (MC4R), and leptin and leptin receptor genes (LEP and LEPR).
|
22020349 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The INSIG2 (INSIG2 is primarily involved in the regulation of fatty acid and cholesterol synthesis) gene is suggested to be obesity related.
|
21978759 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although INSIG2 polymorphisms do not consistently associate with BMI, the observation of an association with glucose concentration would support a role for this gene in the metabolic complications of obesity.
|
20645959 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease in patients with pre-existing CVD.
|
20920244 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 15.1% of participants were overweight or obese at age 16 y.No associations with INSIG2 were found.
|
20007308 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a whole-genome scan, a single nucleotide polymorphism (SNP) (rs7566605) upstream of the insulin-induced gene 2 (INSIG2) was shown to influence body mass index and obesity in the Framingham Heart Study, with replication of these results in an additional 4 of 5 studies.
|
20858904 |
2010 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
|
19851442 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans.
|
19772594 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With a focus on obesity we describe some of the recently reported gene-environment interactions for polymorphisms identified in the FTO and INSIG2 genes.
|
19596186 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, we investigated the association of the INSIG2 rs7566605 polymorphism with obesity- and lipid-related traits in Danish and Estonian children (930 boys and 1,073 girls) from the European Youth Heart Study (EYHS), a school-based, cross-sectional study of pre- and early pubertal children.
|
19197262 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One particularly interesting single nucleotide polymorphism (SNP), rs7566605, located 10 kb upstream of INSIG2 was reported to have the strongest association with obesity among 86 604 SNP, while the relationship with dyslipidaemia is uncertain.
|
18570692 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rs7566605 was not significantly associated with obesity in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in INSIG2 with both BMI and ABDCIR.
|
20028541 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our finding is supported by the recent involvement of the INSIG2 gene in obesity in the general population and implicates SREBP-controlled lipogenesis in drug-induced metabolic adverse effects.
|
18195716 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.
|
19360016 |
2009 |