|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our finding is supported by the recent involvement of the INSIG2 gene in obesity in the general population and implicates SREBP-controlled lipogenesis in drug-induced metabolic adverse effects.
|
18195716 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO.
|
18325910 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.
|
19399648 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have suggested some candidate genes for obesity- and metabolic-related traits, including the insulin-induced gene (INSIG2), melanocortin 4 receptor gene (MC4R), and leptin and leptin receptor genes (LEP and LEPR).
|
22020349 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently a large genetic association study showed evidence for association of the single nucleotide polymorphism (SNP) rs7566605, which lies 10 Kb 5' to the first exon of the insulin-induced gene 2 (INSIG-2), with obesity in several cohorts.
|
17137505 |
2006 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a genetic variation upstream of insulin-induced gene 2 (INSIG2) (rs7566605) has been reported to be associated with obesity in four separate cohorts.
|
17489846 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites.
|
22695173 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms play no apparent role in the development of common forms of obesity in the Danish population.
|
18682847 |
2008 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The INSIG2 (INSIG2 is primarily involved in the regulation of fatty acid and cholesterol synthesis) gene is suggested to be obesity related.
|
21978759 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.
|
25062423 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The K121Q polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 gene and the rs7566605 genotype located near insulin-induced gene 2 have been shown to be associated with insulin resistance and obesity.
|
19107338 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs7566605 marker, located near the INSIG2 gene, has been found to be associated with obesity, making it also a potential genetic determinant for MetS.
|
18096054 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The goal of the study reported here was to assess the role of the INSIG2 single nucleotide polymorphism (SNP) in susceptibility to obesity in the prospective longitudinal Atherosclerosis Risk in Communities (ARIC) study (n = 14,566) and in three other cohorts: the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3,888), the Genetic Epidemiology Network of Arteriopathy (GENOA) study (n = 4,766), and extremely obese and lean individuals ascertained at the University of Ottawa (n = 1,502).
|
19523229 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The possible role in obesity of a common genetic variant near the INSIG2 gene and the discovery of the BBS9 gene are also discussed.
|
17411394 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans.
|
19772594 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This supports and extends the original finding that there is an association between measures of obesity and INSIG2 rs7566605 and further implicates this polymorphism in fat regulation.
|
19105843 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
|
18615239 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population.
|
18514965 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified a 3-locus interaction on obesity in GMDR analyses (P = 0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2.
|
25028659 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed no difference in the genotype frequency of rs7566605 of INSIG2 between obese subjects and population-based controls from Utah.
|
18239574 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity.
|
16614226 |
2006 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With a focus on obesity we describe some of the recently reported gene-environment interactions for polymorphisms identified in the FTO and INSIG2 genes.
|
19596186 |
2009 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Within the DPP study population, common variants in FTO and INSIG2 are nominally associated with quantitative measures of obesity, directly and possibly by interacting with metformin or lifestyle intervention.
|
18839134 |
2008 |