|
Adenoid Cystic Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Polycystic Ovary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Malignant neoplasm of salivary gland
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
Moreover, endogenous IPS-1 cleavage has not been demonstrated in the context of HCV infection in vitro or in vivo.
|
16585524 |
2006 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
First, using IPS-1 knockout mice, we revealed that IPS-1 was essential for type III IFN production by mouse hepatocytes and CD8(+) dendritic cells (DCs) in response to cytoplasmic HCV RNA.
|
24532585 |
2014 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
A dominant active mutant of interferon (IFN) regulatory factor 7 (IRF7) and a negative regulator of HCV replication, VAP-C (Vesicle-associated membrane protein-associated protein subtype C), were fused with the C-terminal region of IPS-1 (IFNβ promoter stimulator-1), which includes an HCV protease cleavage site that was modified to be localized on the ER membrane, and designated cIRF7 and cVAP-C, respectively.
|
21253612 |
2011 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
This cell culture adapted virus enabled us to efficiently infect primary human hepatocytes, as demonstrated using the RFP-NLS-IPS reporter protein and intracellular HCV RNA quantification.
|
23940646 |
2013 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
HCV infection is supported by viral strategies to evade the innate antiviral response wherein the viral NS3.4A protease complex targets and cleaves the interferon promoter stimulator-1 (IPS-1) adaptor protein to ablate signaling of interferon alpha/beta immune defenses.
|
17289677 |
2007 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
CIFN exhibits increased anti-HCV potency over IFN-alpha2a and PEG-IFN through maximal and distinct induction of ISG expression and enhanced intracellular innate antiviral response, while protecting IPS-1 from HCV proteolysis.
|
19043919 |
2008 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
Although both IFNARko and IPS-1ko hepatocytes showed a reduced induction of type I interferons in response to viral infection, only IPS-1-/- cells circumvented cell death from HCV cytopathic effect and significantly improved J6JFH1 replication, suggesting IPS-1 to be a key player regulating HCV replication in mouse hepatocytes.
|
21731692 |
2011 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate whether genetic polymorphisms of the inducible nitric oxide synthase (iNOS) gene NOS2A could be associated with a sustained virological response (SVR) among patients infected with hepatitis C virus genotypes 1 and 2 (HCV-1 and HCV-2) who were treated with peginterferon plus ribavirin (PEG-IFNα-RBV).
|
23918539 |
2013 |
|
Asthma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Severe asthma was associated with the highest levels of iNOS protein and mRNA, although the index of iNOS mRNA to arginase2 mRNA most strongly differentiated severe from milder asthma.
|
22092728 |
2012 |
|
Asthma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We analysed several polymorphisms mainly in the promoter region of the inducible NO synthase (NOS2, iNOS) gene and investigated their associations with asthma and/or atopic phenotypes.
|
17177683 |
2006 |
|
Asthma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining revealed expression of iNOS proteins mainly in epithelial cells in the airways, while it was mainly expressed in macrophages in the alveolar region in the snBA group.
|
30667100 |
2019 |
|
Asthma
|
0.070 |
Biomarker
|
disease |
BEFREE |
To further clarify the role of IPS-1 signalling, we inoculated IPS-1<sup>-/-</sup> and WT mice with PVM in early-life, and again in later-life, to model the association between bronchiolitis and asthma.
|
28539639 |
2017 |
|
Asthma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association of iNOS promoter gene polymorphisms and FeNO levels in Japanese asthmatics before the introduction of asthma treatment.
|
27021121 |
2016 |
|
Asthma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of inducible nitric oxide synthases (iNOS) gene repeat polymorphisms with asthma.
|
17189532 |
2007 |
|
Asthma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
BNP stimulated the release of acetylcholine (210.7 ± 11.1%) from BEAS-2B cells that in turn increased MYPT1 and iNOS gene/protein expression and enhanced NO levels in asthmatic ASM supernatant (35.0 ± 13.0%).
|
24074453 |
2014 |
|
Celiac Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In support of these observations, patients with CD expressed more iNOS protein than those with IDA (159.7+/-14.9% vs. 69.8+/-20%, p<0.05).
|
15936309 |
2005 |
|
Celiac Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study, which provides evidence that the effect of G on iNOS gene transcription in IFN-gamma-stimulated RAW 264.7 cells can be ascribed to all three transcription factors, may contribute to lead to new insights into the molecular mechanisms governing the inflammatory process in celiac disease.
|
16284791 |
2006 |
|
Celiac Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Duodenal biopsy specimens from untreated and on gluten-free diet patients with celiac disease and controls were respectively processed for S100B and inducible nitric oxide synthase (iNOS) protein expression and nitrite production.
|
17678654 |
2007 |
|
Cystic Fibrosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
This is the first study to measure inducible nitric oxide synthase (iNOS) gene and protein expression quantitatively in primary epithelial cells from very young children with cystic fibrosis (CF).
|
16517573 |
2006 |
|
Cystic Fibrosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Human neutrophils were activated by incubation with cytokines, added to monolayers of normal (16HBE14o-) and CF (CFBE41o-) bronchial epithelial cells and co-cultured for up to 72 h. Marked up-regulation of iNOS protein expression was seen in normal bronchial epithelial cells following neutrophil co-culture but the CF cells showed a significantly smaller increase (p<0.001).
|
10657009 |
2000 |