|
Cystic Fibrosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To understand better the poor resistance to infections in the CF lung, the expression of the iNOS gene was investigated in explanted lungs from patients with cystic fibrosis (n = 13), bronchiectasis (n = 3), emphysema (n = 14), and in normal lungs (n = 8).
|
9614386 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Yet, iPS generation from patients with type 2 diabetes (T2D) has not been demonstrated.
|
22308265 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
This pilot study analyzed whether a 3-month endurance training can affect iNOS protein and NO metabolite levels in the vastus lateralis muscle of insulin-independent T2DM men, thereby affecting the patients` glycemic control.
|
27782779 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We previously reported the association of the Z-2 allele of the promoter dinucleotide repeat in the Aldose reductase (ALR2) gene, the (CCTTT)₁₅ allele in the promoter of inductible nitric oxide synthase (iNOS) gene, and the (GT)₁₃ promoter polymorphism in the tumor necrosis factor β (TNFB) gene with an increased risk for diabetic retinopathy (DR), and the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene and the (GT)₉ allele of the TNFB gene with low-risk for DR in a hospital-based self-reported type 2 diabetes mellitus (T2DM) patients.
|
21067489 |
2010 |
|
Malaria
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide substitution, -954G-->C, in the iNOS promoter was rare in Thai patients with malaria.
|
12195390 |
2002 |
|
Malaria
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we experimentally elucidate that iNOS promoter polymorphisms are associated with risk of malaria; employing mutation specific genotyping, functional interplay using western blot and RT-PCR, quantitative estimation of NO, total antioxidant content (TAC) and reactive oxygen species (ROS).
|
29268202 |
2018 |
|
Malaria
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.
|
15482399 |
2004 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Quantitation of iNOS transcripts and iNOS enzyme activity in non-cancerous mucosa of gastric cancer patients revealed a significant increase in iNOS transcripts and iNOS activity only in the mucosa of patients with stomach cancer of the intestinal type but not in the diffuse type.
|
14760971 |
2003 |
|
Malignant neoplasm of stomach
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A CT or TT polymorphism at position 150 in the iNOS gene significantly increases the risk of GC and may be a marker for GC susceptibility.
|
23002365 |
2012 |
|
Malignant neoplasm of stomach
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Rafiei et al recently described an association between the presence of the C150T polymorphism of the inducible nitric oxide synthase (iNOS) gene and Helicobacter pylori (H. pylori) induced gastric cancer.
|
23372371 |
2013 |
|
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The Cd contents, expression of melanoma-associated differentiation gene 5 (MDA5) and its downstream signaling molecules (interferon promoter-stimulating factor 1 (IPS-1), transcription factors interferon regulatory factor 3 (IRF3), and nuclear factor kappa-light chain-enhancer of activated B cells (NF-κB)), the content of cytokines (interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and beta interferon (IFN-β)), protein levels of heat shock proteins (HSPs), levels of malondialdehyde (MDA), activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), and histopathological changes of spleens were detected on the 20th, 40th, and 60th day.
|
29032405 |
2018 |
|
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Further mechanistic analysis showed that TRIP4 promoted melanoma growth through modulation of COX-2 and iNOS expression partially by activating NF-κB signaling indirectly and partially by the direct anchoring of itself at COX-2 and iNOS promoter via synergy with p300.
|
28899685 |
2018 |
|
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
NS3 mutants lacking the helicase domain retained the ability to control virus signaling initiated by retinoic acid-inducible gene-I (RIG-I) or melanoma differentiation antigen 5 and suppressed the downstream activation of interferon regulatory factor-3 (IRF-3) and nuclear factor kappaB (NF-kappaB) through the targeted proteolysis of IPS-1.
|
17289677 |
2007 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.
|
12490535 |
2003 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes.
|
17174475 |
2007 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these in vitro findings, blocking mGlu<sub>5</sub> attenuated the anti-inflammatory effects of T10 in an LPS-induced PD model and blocked the decreases in the number and morphology of ionized calcium binding adaptor molecule 1-positive microglia and LPS-induced iNOS protein expression caused by T10 treatment.
|
29649522 |
2018 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
A significant increase of iNOS gene expression was observed in nasopharyngeal exudate cells obtained from infants during the acute phase of RSV bronchiolitis.
|
10410996 |
1999 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Experiments with bone marrow chimeras indicated that RSV-induced lung pathology was most severe when IPS-1 expression was lacking in both immune and nonimmune cell populations.
|
23136205 |
2012 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Thus, both UTP- and iNOS-generated reactive species contribute to ENaC down-regulation in RSV-infected airway epithelial cells.
|
19131335 |
2009 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Quantitation of iNOS transcripts and iNOS enzyme activity in non-cancerous mucosa of gastric cancer patients revealed a significant increase in iNOS transcripts and iNOS activity only in the mucosa of patients with stomach cancer of the intestinal type but not in the diffuse type.
|
14760971 |
2003 |
|
Stomach Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Rafiei et al recently described an association between the presence of the C150T polymorphism of the inducible nitric oxide synthase (iNOS) gene and Helicobacter pylori (H. pylori) induced gastric cancer.
|
23372371 |
2013 |
|
Stomach Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A CT or TT polymorphism at position 150 in the iNOS gene significantly increases the risk of GC and may be a marker for GC susceptibility.
|
23002365 |
2012 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A functional variant of the iNOS gene flanking region is associated with LAD coronary artery disease: an autopsy study.
|
14636285 |
2003 |
|
Coronary Artery Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Sixty-four bovine teeth were prepared for full crown restoration (7.0±0.5 mm in height, 8.0 mm in cervical diameter, and 4.2 mm in incisal diameter) and were divided into two groups: CAD/CAM automation technology, IPS e.max CAD (CAD), and isostatic injection by heat technology, IPS e.max Press (PRESS).
|
27802123 |
2018 |
|
Coronary Artery Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Comparing initial K<sub>Ic</sub> values, lithium disilicate ceramic IPS e.max CAD showed significantly the highest and leucite-reinforced ceramic IPS Empress CAD significantly the lowest K<sub>Ic</sub> values (<i>p</i><0.001).
|
30849010 |
2019 |