|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Polycystic Ovary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Adenoid Cystic Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Salivary Gland Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Malignant neoplasm of salivary gland
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Additionally, iNOS gene therapy sensitized MDA-MB-231-luc-D3H1 tumors to docetaxel treatment.
|
28325291 |
2017 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
First, using IPS-1 knockout mice, we revealed that IPS-1 was essential for type III IFN production by mouse hepatocytes and CD8(+) dendritic cells (DCs) in response to cytoplasmic HCV RNA.
|
24532585 |
2014 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
This cell culture adapted virus enabled us to efficiently infect primary human hepatocytes, as demonstrated using the RFP-NLS-IPS reporter protein and intracellular HCV RNA quantification.
|
23940646 |
2013 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate whether genetic polymorphisms of the inducible nitric oxide synthase (iNOS) gene NOS2A could be associated with a sustained virological response (SVR) among patients infected with hepatitis C virus genotypes 1 and 2 (HCV-1 and HCV-2) who were treated with peginterferon plus ribavirin (PEG-IFNα-RBV).
|
23918539 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We found that iPS genes promote sphere-formation, proliferation, colony formation, migration of human CRC cells in vitro and tumor growth in vivo.
|
23307247 |
2013 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In further support of an important role of iNOS, we found iNOS protein to be highly expressed in NPM-ALK(+) T-cell lymphoma cell lines and in 79% of primary tumours but not in human T lymphocytes.
|
23338972 |
2013 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
A dominant active mutant of interferon (IFN) regulatory factor 7 (IRF7) and a negative regulator of HCV replication, VAP-C (Vesicle-associated membrane protein-associated protein subtype C), were fused with the C-terminal region of IPS-1 (IFNβ promoter stimulator-1), which includes an HCV protease cleavage site that was modified to be localized on the ER membrane, and designated cIRF7 and cVAP-C, respectively.
|
21253612 |
2011 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
Although both IFNARko and IPS-1ko hepatocytes showed a reduced induction of type I interferons in response to viral infection, only IPS-1-/- cells circumvented cell death from HCV cytopathic effect and significantly improved J6JFH1 replication, suggesting IPS-1 to be a key player regulating HCV replication in mouse hepatocytes.
|
21731692 |
2011 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We investigated the combination of inducible nitric oxide synthase (iNOS) gene transfer, driven by a strong constitutive promoter (cytomegalovirus; CMV) with the DNA cross-linking agent cisplatin in mouse and human tumour cell lines.
|
19062185 |
2009 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
CIFN exhibits increased anti-HCV potency over IFN-alpha2a and PEG-IFN through maximal and distinct induction of ISG expression and enhanced intracellular innate antiviral response, while protecting IPS-1 from HCV proteolysis.
|
19043919 |
2008 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
HCV infection is supported by viral strategies to evade the innate antiviral response wherein the viral NS3.4A protease complex targets and cleaves the interferon promoter stimulator-1 (IPS-1) adaptor protein to ablate signaling of interferon alpha/beta immune defenses.
|
17289677 |
2007 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
Moreover, endogenous IPS-1 cleavage has not been demonstrated in the context of HCV infection in vitro or in vivo.
|
16585524 |
2006 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
PCR analysis of organ tissue after intra-tumoural injection of WAF1/iNOS showed that vector sequences were detected in all tissue tested; however, Western blot analysis revealed that iNOS protein levels were significantly increased only in tumour and the surrounding dermal tissue that had been exposed to the 4 Gy inducing dose.
|
15170738 |
2004 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The objectives of this study were to further characterize the effects of iNOS gene transfer on the radiosensitivity of human colorectal cancer cells in vitro and tumors grown in athymic nude mice.
|
14973054 |
2004 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Also, in 50 untreated patients, iNOS protein expression did not correlate with the AIs of the tumors.
|
12182114 |
2003 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Western and Northern blot analyses confirmed the up-regulation of the iNOS protein and gene in the tumor specimens as compared with normal mucosa.
|
12598314 |
2003 |
|
Asthma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining revealed expression of iNOS proteins mainly in epithelial cells in the airways, while it was mainly expressed in macrophages in the alveolar region in the snBA group.
|
30667100 |
2019 |
|
Asthma
|
0.070 |
Biomarker
|
disease |
BEFREE |
To further clarify the role of IPS-1 signalling, we inoculated IPS-1<sup>-/-</sup> and WT mice with PVM in early-life, and again in later-life, to model the association between bronchiolitis and asthma.
|
28539639 |
2017 |
|
Asthma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association of iNOS promoter gene polymorphisms and FeNO levels in Japanese asthmatics before the introduction of asthma treatment.
|
27021121 |
2016 |