|
Adenocarcinoma Of Esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium.
|
20332323 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Two major SBP1 isoforms were detected, with an acidic isoform (457) being significantly down-regulated in lung adenocarcinomas compared with normal lung (p = 0.02).
|
14991897 |
2004 |
|
Benign Ovarian Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
The percent of anti-SBP1-positive sera was higher in POF (P = 0.02), irregular ovulation (P = 0.001), unexplained causes (P = 0.02), late (III-IV)-stage OvCa (P = 0.02) but was not significant in endometriosis, benign ovarian tumors/cysts, early stage (I-II) OvCa or uterine cancer compared to healthy controls.
|
27965399 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrant localization patterns of Cx-26 and Drg-1 were observed in bladder tumors.
|
18288642 |
2008 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We have investigated protein kinase C (PKC) signaling, a putative differentiation-related and metastasis suppressor gene Cap43/NDRG1/Drg-1, and Y-box binding protein-1 (YB-1) to identify new molecular targeting for breast cancer.
|
18224398 |
2008 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Together, our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer.
|
15184886 |
2004 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, our immunohistochemical analysis revealed that PTEN expression correlates significantly with Drg-1 in both prostate and breast cancer cases.
|
15520163 |
2004 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer.
|
22481237 |
2012 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ability of anti-SBP1 alone to discriminate infertility or OvCa from controls or when combined with anti-TP53 and CA125, to identify OvCa was evaluated by comparing the area under the curve (AUC) in ROC analysis.
|
27965399 |
2017 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We also observed high accumulation of ARP-modified SBP1 in the RBCs of patients with chronic kidney disease.
|
28867194 |
2017 |
|
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that SBP1 was mainly located on epithelial cells and was significantly increased in patients with active CD.SBP1 was the target gene of miR-122. miR-122 expression was downregulated while SBP1 expression was upregulated under TNBS-induced colitis or oxidative stress.
|
31019652 |
2019 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Colon Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The tumor metastasis suppressor gene Drg-1 has been shown to suppress metastasis without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer.
|
17178897 |
2006 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that SBP1 has tumor suppressor functions that are inhibited in colorectal cancer through epigenetic silencing.
|
19924303 |
2009 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that higher expression of SBP1 is associated with differentiation of the normal colonic epithelia and may be a positive prognostic factor for survival in stage III colorectal carcinoma.
|
18435490 |
2008 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003).
|
18435490 |
2008 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that long-term administration of SBP (1-2 pills three times daily, for at least 6 months) for treatment of CAD is effective and safe, with a significant, long-term effect.
|
29444778 |
2018 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that SBP1 was mainly located on epithelial cells and was significantly increased in patients with active CD.SBP1 was the target gene of miR-122. miR-122 expression was downregulated while SBP1 expression was upregulated under TNBS-induced colitis or oxidative stress.
|
31019652 |
2019 |
|
Dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of a Novel SBP1-Containing SCF<sup>SFB</sup> Complex in Wild Dwarf Almond (<i>Prunus tenella</i>).
|
31708966 |
2019 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The percent of anti-SBP1-positive sera was higher in POF (P = 0.02), irregular ovulation (P = 0.001), unexplained causes (P = 0.02), late (III-IV)-stage OvCa (P = 0.02) but was not significant in endometriosis, benign ovarian tumors/cysts, early stage (I-II) OvCa or uterine cancer compared to healthy controls.
|
27965399 |
2017 |