|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome.
|
30400135 |
2018 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
N-myc downstream regulated gene 1 (NDRG1), also known as Cap43, Drg-1, and rit42, is expressed in various normal tissues and cancers, in which it is often associated with a favorable prognosis.
|
21784644 |
2011 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
CD44s is decreased in both PIN and cancer; Drg-1, E-cadherin, KAI-1, RKIP, and SSeCKS show similar expression between benign epithelia and PIN, but are downregulated in invasive cancer; whereas, maspin, MKK4, Nm23 and PTEN are upregulated in PIN and downregulated in cancer.
|
22886631 |
2012 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression.
|
23483240 |
2013 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Expression of Drg-1 has also been found to have a significant inverse correlation with metastasis or invasiveness in various types of human cancer.
|
17178897 |
2006 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Our immunohistochemical analysis on prostate cancer specimens revealed that nuclear expression of ATF3 was inversely correlated to Drg-1 expression and positively correlated to metastases.
|
17178897 |
2006 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we explored the possibility that PTEN controls tumor metastasis by regulating the expression of the Drg-1 gene.
|
15520163 |
2004 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells.
|
16707596 |
2006 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Moreover, we used RBE, a human ICC cell line, to study the effects of SBP1 knockdown on ICC cell proliferation, migration and invasion.
|
30662608 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
CXCR4 expression was inhibited by SBP1 and restored the migration and invasion ability of HCC cells through activation of AKT signaling.
|
30034941 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
However, SBP1 did not influence the invasion, phagocytosis or intracellular survival of SS2.
|
29886087 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Functional studies revealed that overexpression of Drg-1 in metastatic colon cancer cells reduced in vitro invasion through Matrigel and suppressed in vivo liver metastases in nude mice.
|
10676663 |
2000 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In freshly isolated clinical HCC tissues, decreased SBP1 was linked with increased GPX1 activity and correlated with vascular invasion.
|
22512980 |
2012 |
|
Malignant tumor of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
The tumor metastasis suppressor gene Drg-1 has been shown to suppress metastasis without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer.
|
17178897 |
2006 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Malignant tumor of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Malignant tumor of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Importantly, stage III colorectal cancer patients with low tumor-SBP1 expression had significantly shorter disease-free and overall survival as compared with those patients with high tumor-SBP1 expression (p = 0.04 and 0.03, respectively).
|
18435490 |
2008 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas.
|
14991897 |
2004 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The results showed that SBP1 expression was significantly downregulated in ICC tumor tissues, especially in tumor tissues from ICC patients with recurrence or tumor vascular invasion, compared with that in peritumoral tissues (all <i>P</i> < 0.05).
|
30662608 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumor tissue microarrays indicated that SBP1 was an independent risk factor for overall survival and disease recurrence; patients with lower SBP1 expression experienced shorter overall survival periods and higher rates of disease recurrence (P < 0.001).
|
22512980 |
2012 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |