|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined 8 SNPs related to obesity: GHRL rs696217, PPARG rs1175544, ADIPOQ rs2241766, ADIPOQ rs1501299, PPARD rs2016520, APOA5 rs662799, BRAP rs3782886, and ITGB2 rs235326.
|
27245511 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the association of A-604G SNP of GHRL promoter region with serum ghrelin levels and the risk of obesity in a Mexican population.
|
28597412 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity.
|
26255942 |
2015 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism.
|
23257630 |
2013 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin.
|
23084284 |
2013 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relationships between obesity and common genomic variants of GHRL and GHS-R genes have been studied.
|
21345363 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in preproghrelin and ghrelin gene could be responsible for obesity, insulin resistance and low ghrelin levels observed in some individuals.
|
19049992 |
2009 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome.
|
17884032 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous studies suggested that polymorphisms in the coding region of the preproghrelin were involved in the etiology of obesity and might modulate glucose-induced insulin secretion.
|
18071345 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variation in the preproghrelin gene is not associated with juvenile-onset obesity, type 2 diabetes or related phenotypes among the examined Danish Caucasian subjects.
|
15820771 |
2005 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity.
|
16459454 |
2005 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the preproghrelin/ghrelin gene associated with obesity in humans.
|
11502844 |
2001 |
|
Obesity
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Depressive disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the 72Met allele of the preproghrelin Leu72Met polymorphism may be associated with rehabilitation of depression in male Chinese Han adolescents after the natural disaster.
|
28570394 |
2017 |
|
Congestive heart failure
|
0.310 |
Biomarker
|
disease |
BEFREE |
Ghrelin is a novel growth hormone-releasing peptide administered to treat chronic heart failure (CHF).
|
24465706 |
2014 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
These four GHRL gene SNPs were not associated with SZ in this Chinese Han population.
|
22369141 |
2012 |
|
Congestive heart failure
|
0.310 |
Therapeutic
|
disease |
CTD_human |
Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol.
|
20572026 |
2010 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
CTD_human |
Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment.
|
19272368 |
2009 |
|
heavy drinking
|
0.310 |
Biomarker
|
disease |
BEFREE |
The present findings are the first to disclose an association between the pro-ghrelin and GHS-R1A genes and heavy alcohol use, further strengthening the role of the ghrelin system in addictive behaviors and brain reward.
|
18828808 |
2008 |
|
heavy drinking
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The present findings are the first to disclose an association between the pro-ghrelin and GHS-R1A genes and heavy alcohol use, further strengthening the role of the ghrelin system in addictive behaviors and brain reward.
|
18828808 |
2008 |
|
Cachexia
|
0.310 |
Therapeutic
|
phenotype |
CTD_human |
Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia.
|
17347304 |
2007 |
|
Cachexia
|
0.310 |
AlteredExpression
|
phenotype |
LHGDN |
Increased plasma ghrelin level in lung cancer cachexia.
|
12576449 |
2003 |