Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of the N-myc oncogene in neuroblastoma cell lines SH-SY5Y and BE(2)-C, following treatment with retinoic acid, was paralleled by down-regulation of MRP gene expression, contrasting with increased expression of the MDR1 gene.
|
7923112 |
1994 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study offers compelling evidence that (a) IGR-N-91 is a human neuroblastoma xenograft model able to induce metastasis in nude mice, (b) an increase in MYCN and MDR1 transcripts levels is associated with the metastatic process, and (c) IGR-N-91 provides a biological tool for the study of gene activations during tumor dissemination in neuroblastoma.
|
8174136 |
1994 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry.
|
1374683 |
1992 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A panel of monoclonal antibodies (MAbs) to P-glycoprotein was developed by immunization of mice with multidrug-resistant human neuroepithelioma and neuroblastoma cells.
|
1348013 |
1992 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas.
|
1678252 |
1991 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The role, if any, of increased expression of mdr-1 in the acquisition of multidrug resistance in neuroblastoma remains unclear.
|
2185879 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA transcription may occur spontaneously after onset, suggesting that certain NB tumors could be resistant to antineoplastic drugs at onset.
|
1974410 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Many of the neuroblastoma samples were also evaluated for N-myc amplification but there was no correlation between N-myc copy number and the level of MDR1 mRNA expression.
|
2295903 |
1990 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For the 26 treated neuroblastomas, the number of nonresponsive tumors was found to be significantly higher among those with high levels of MDR1 mRNA.
|
2778826 |
1989 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 RNA levels were occasionally elevated in other untreated cancers, including neuroblastoma, acute lymphocytic leukemia (ALL) in adults, acute nonlymphocytic leukemia (ANLL) in adults, and indolent non-Hodgkin's lymphoma.
|
2562856 |
1989 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An increase in the level of mdr1 mRNA was observed after retinoic acid treatment of four neuroblastoma cell lines, including the SK-N-SH cell line.
|
2573830 |
1989 |