|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sections from formalin-fixed paraffin-embedded tumor blocks from 52 neuroblastoma cases (17 with localized, 35 with advanced disease) were subjected to immunohistochemistry for P-gp and GST-pi expressions.
|
12078865 |
2002 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multidrug resistance protein 1 has been previously implicated in the development of drug resistance, particularly with regard to influencing clinical outcomes in neuroblastoma.
|
21317832 |
2011 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meningioma cells frequently co-expressed P-gp and MRP1, while, most of the neuroblastoma cell lines express higher P-gp but lower MRP1 levels as compared to the other tumor types.
|
12125964 |
2002 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA transcription may occur spontaneously after onset, suggesting that certain NB tumors could be resistant to antineoplastic drugs at onset.
|
1974410 |
1990 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas.
|
1678252 |
1991 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis.
|
11474132 |
2001 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we show that ABCB1 expression represents the primary (sometimes exclusive) resistance mechanism in neuroblastoma cells with acquired resistance to SNS-032.
|
27517323 |
2016 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Many of the neuroblastoma samples were also evaluated for N-myc amplification but there was no correlation between N-myc copy number and the level of MDR1 mRNA expression.
|
2295903 |
1990 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we present the effect of the N-(2-hydroxypropyl) methacrylamide-based polymer conjugate with P-gp inhibitor ritonavir (RIT) on the increase of free doxorubicin (DOX) and polymer-bound DOX cytotoxicity in the human neuroblastoma 4 cell line and its resistant clones to different cytostatics.
|
28901962 |
2017 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts.
|
8761367 |
1996 |
|
Neuroblastoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Data from present study suggest that transcriptional inactivation of MDR1 gene due to increased MDR1 promoter methylation may be a contributing factor in pathogenesis and progression of neuroblastoma tumors, and may be used in designing an effective treatment therapy to neuroblastoma patients.
|
17387584 |
2007 |