|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
ATP-binding cassette sub-family B member 1 (ABCB1) is a membrane-associated protein that acts as an efflux transporter for many substrates, including chemotherapeutic agents, anti-epilepsy medicine, antibiotics and drugs for PD.
|
24572589 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy.
|
24300029 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in the group with drug-resistant epilepsy than in the group with drug-responsive epilepsy [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.06, P=0.01].
|
24953225 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, a significant association was observed between ABCB1 (C3435T) rs1045642 and risk of having epilepsy (MTLE-HS and JME pooled cohort; genotypic p-value = 0.0002; allelic p-value = 0.004).
|
24586633 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study does not support any significant association between the MDR1 polymorphism and drug-resistant childhood epilepsy.
|
23465586 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary.
|
24213830 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
|
25223475 |
2014 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
|
23984379 |
2013 |
|
Epilepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The P-gp encoded by the ABCB1 and ABCC2 genes are expressed in drug resistant patients with epilepsy.
|
23717663 |
2013 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a further multivariate analysis, variants in SCN1A, CYP2C9, CYP2C19 and ABCB1 genes were significantly associated with CDRs of PHT under adjustment of age, gender and epilepsy classifications (adjusted r(2) = 20.07%).
|
22966884 |
2012 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between lamotrigine concentrations and ABCB1 polymorphisms in patients with epilepsy.
|
22972536 |
2012 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the association between C3435T and G2677T/A ABCB1 gene polymorphisms and drug resistance in Iranian epilepsy patients.
|
21636342 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we performed the first haplotype meta-analysis to examine the association of haplotypes of ABCB1 common variants with the response to treatment in epilepsy.
|
21391884 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the P-glycoprotein-encoding gene ABCB1 are suspected to be associated with pharmacoresistance phenotypes in epilepsy patients.
|
22033938 |
2011 |
|
Epilepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that ABCB1 3435-TT is associated with decreased plasma CBZ levels in Chinese patients with epilepsy.
|
21493161 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of ABCB1 and PXR genetic polymorphisms with response to the carbamazepine (CBZ) or sodium valproate (VPA) monotherapy in epilepsy.
|
21316268 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the ABCB1 rs3789243 C>T, C1236T, G2677T/A, rs6949448 C>T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
|
21530324 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant differences were observed in the frequencies of genotype, allele, haplotype, or diplotype of ABCB1 polymorphisms between patients with drug-resistant and drug-responsive epilepsy (p>0.05).
|
21420937 |
2011 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
|
21388909 |
2011 |
|
Epilepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
ABCB1 genotyping for epileptic patients is not warranted.
|
20491876 |
2010 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our finding disproves a general association between ABCB1 polymorphisms and drug response in epilepsy patients.
|
20417680 |
2010 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, patients with symptomatic epilepsies with the ABCB1_3435CT or TT genotypes had a lower risk of drug-resistance than those with the CC genotype.
|
20064729 |
2010 |
|
Epilepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition to Pgp, increased expression of several multidrug resistance-associated proteins (MRPs) has been determined in epileptogenic brain regions of patients with pharmacoresistant epilepsy.
|
20080116 |
2010 |
|
Epilepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We failed to show an association between the ABCB1 C3435T polymorphism and the risk of drug-resistance suggesting a revision in contribution of this polymorphism in the multi-drug transporters hypothesis of pharmacoresistance to AEDs in epilepsy.
|
20605481 |
2010 |