Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells.
|
29393336 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.
|
30182951 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analysis was performed to detect the expression levels of phosphatidylinositol 3‑kinase (PI3K), phospho (p)‑PI3K, RAC‑alpha serine/threonine‑protein kinase (AKT), p‑AKT and NF‑κB inhibitor α (IκBα) in osteosarcoma cells transfected with H19 siRNA.
|
29568924 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis revealed that lnPTENP1 transfection regulated osteosarcoma cell growth via the PI3K/AKT signaling pathway.
|
29805503 |
2018 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the results of the present study indicate that the expression of miRNA-21, PI3K and AKT is increased in the osteosarcoma cell line MG-63, which results in reduced expression of PTEN and increased expression of proteins in the PI3K/AKT signaling pathway, and thus increases the aggressiveness of osteosarcoma cells.
|
29434694 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.
|
29845216 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mTOR signaling pathway.
|
29207060 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ISL could retard proliferation and promote apoptosis of U2OS cells possibly by suppressing the PI3K/Akt signalling pathway, indicating that it might be a potential therapeutic agent for osteosarcoma treatment.
|
29936511 |
2018 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relative protein expression level of p-PI3K, p-Akt, P53 and Bcl-2 in osteosarcoma cells after transfection with lncRNA- NC or lncRNA-LINC00628 were detected by Western blot.
|
30280767 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data revealed for the first time that MALAT1 increases stem cell-like properties by up-regulating RET via sponging miR-129-5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment.
|
30481748 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway.
|
29412697 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAS area showed KRAS and BRAF mutations in two different segments, and osteosarcoma tested positive for well known PIK3CA, KRAS and CDH1 alterations.
|
30268473 |
2018 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3β (PI3K/AKT/GSK3β) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion.
|
29323740 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma.
|
30092789 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma.
|
30014744 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We discovered that TIIA inhibited osteosarcoma cell survival through class I PI3K and Akt signaling pathways.
|
30258193 |
2018 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
|
28256910 |
2017 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
29213214 |
2017 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fractalkine induced cell migration by upregulating intercellular adhesion molecule-1 (ICAM-1) expression via CX3CR1/PI3K/Akt/NF-κB pathway in human osteosarcoma cells.
|
28903329 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we further found that those effects on osteosarcoma by NRSN2 are associated with the dysregulated PI3K/AKT/mTOR signaling and Wnt/β-catenin signaling.
|
28401012 |
2017 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A panel of inhibitors of PI3K and Akt treated osteosarcoma cells and blocked kinase activity.
|
28289332 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells.
|
28623712 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management.
|
28565856 |
2017 |
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.
|
28932123 |
2017 |
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Equally importantly, PTEN is the most significant negative regulator of PI3K/Akt signaling cascade, the constitutively activated pathway in osteosarcoma.
|
29029415 |
2017 |