|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
Biomarker
|
disease |
BEFREE |
Increased cDC2 numbers due to CD11c-restricted Wnt4 deficiency increased IL-5 production, group 2 innate lymphoid cell expansion, and host resistance to the hookworm parasite <i>Nippostrongylus brasiliensis</i> Collectively, these data uncover a novel and unexpected role for Wnt4 in cDC subset differentiation and type 2 immunity.
|
31175162 |
2019 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study.
|
18182450 |
2008 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study.
|
18182450 |
2008 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report.
|
16959810 |
2007 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report.
|
16959810 |
2007 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman.
|
15317892 |
2004 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman.
|
15317892 |
2004 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman.
|
15317892 |
2004 |
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Mullerian Aplasia and Hyperandrogenism
|
0.710 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4.
|
18179883 |
2008 |
|
Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4.
|
18179883 |
2008 |
|
Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman.
|
15317892 |
2004 |
|
Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Dwarfism
|
0.400 |
Biomarker
|
disease |
CTD_human |
These studies demonstrate that Wnt4 overexpression leads to dwarfism in mice.
|
17505543 |
2007 |
|
Dwarfism
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
Carcinoma, Ovarian Epithelial
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
A total of eight tag single-nucleotide polymorphisms (SNPs) were genotyped successfully, and both single SNP and haplotype analyses were performed to detect the potential association of variations in the WNT4 gene with EOC.
|
30457351 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.320 |
Biomarker
|
disease |
CTD_human |
Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8).
|
25581431 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8).
|
25581431 |
2015 |
|
Kidney Diseases
|
0.310 |
Biomarker
|
group |
BEFREE |
WNT4 Expression in Primary and Secondary Kidney Diseases: Dependence on Staging.
|
31067548 |
2019 |
|
Kidney Diseases
|
0.310 |
Biomarker
|
group |
CTD_human |
Wnt4 expression is induced throughout the collecting ducts in four murine models of renal injury that produce tubulointerstitial fibrosis: folic acid-induced nephropathy, unilateral ureteral obstruction, renal needle puncture, and genetic polycystic kidney disease.
|
11832423 |
2002 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Female Urogenital Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Development of the mammalian female reproductive tract.
|
16002989 |
2005 |
|
Endometriosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This might constitute the first step towards identifying polymorphism combinations that predispose to endometriosis (IFNG (CA) repeat, GSTM1 null genotype, GSTP1 rs1695, WNT4 rs16826658 and WNT4 rs2235529) in a large cohort of patients with well-defined inclusion criteria.
|
31821471 |
2020 |