|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings thus raise the possibility that PON1 may be of importance in both the genetic and acquired predisposition to premature atherosclerosis and neuropathy in diabetes.
|
9712341 |
1998 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In recent case-control studies serum PON1 concentration and activity were also found to be decreased in coronary heart disease (CHD) independent of the PON1 polymorphism, and in diabetes serum PON1 specific activity decrease is also independent of the PON1 genetic polymorphism.
|
9739487 |
1998 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Low PON1 activities have been found in familial hypercholesterolemia (FH) and diabetes mellitus.
|
10978257 |
2000 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The observed interaction with type 2 diabetes, however, is supporting the hypothesis that the effect of the PON1 192 Arg allele on atherosclerosis is modulated by other risk factors like diabetes.
|
11409295 |
2001 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There were no differences in either the PON1 polymorphisms, PON1 activity and concentration in people with type 1 diabetes in the presence or absence of micro and macro vascular complications of diabetes.
|
11952811 |
2002 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
LHGDN |
The data suggest that 1) PON1 activity loss is an event occurring later in the course of diabetes mellitus; and 2) PON1 does not affect oxidation of circulating LDL, at least in early diabetes mellitus.
|
12679462 |
2003 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that PON1 Q192R polymorphism was not independently associated with MI but further increased the risk of MI among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.
|
15654230 |
2005 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes.
|
16229851 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We noticed smaller PON activity decrease in our newly diagnosed diabetic subjects compared to the previous studies which investigated the alteration of enzyme activity after a longer duration of diabetes mellitus.
|
16357806 |
2005 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It has been reported that human serum paraoxonase (PON1) gene is associated with coronary heart disease (CHD) and diabetes mellitus (DM).
|
16808888 |
2006 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genotyping of 156 Caucasian adolescents with diabetes for seven PON 1 polymorphisms was performed, including that of a novel PON 1 promoter polymorphism A(-1074)G. PON genotypes were related to paraoxonase and arylesterase activities and diabetes complication status.
|
16949520 |
2006 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We have compared the ability of HDL from people with type 2 diabetes (n = 36) with no coronary heart disease (CHD) to metabolize oxidized palmitoyl arachidonyl phosphatidylcholine (ox-PAPC), a major product of LDL oxidation and a PON1 substrate, with that of HDL isolated from healthy control subjects (n = 19) and people with CHD but no diabetes (n = 37).
|
17065348 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Low serum paraoxonase1 (PON1) activity determined by paraoxon substrate is associated with coronary heart disease (CHD), diabetes and systemic lupus erythematosus (SLE) risk.
|
17900266 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The association of PON1 polymorphisms, lower PON1 activity and poorer diabetes control found in patients with macroangiopathy further support the idea of genetic factors contributing to the development of vascular disorders in diabetes.
|
17949258 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The association of PON1 polymorphisms, lower PON1 activity and poorer diabetes control found in patients with macroangiopathy further support the idea of genetic factors contributing to the development of vascular disorders in diabetes.
|
17949258 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Oxidation has been implicated in the onset of diabetes, and it can be hypothesized that PON1 may have a protective effect on diabetes.
|
18290860 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
PON activity was significantly decreased in Type 2 DM group compared to the control group.
|
19003935 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
The PON1 Q/R polymorphism was found to have significant association with hypertension (p=0.046) and chronic constipation (p=0.028) whereas, the L/M polymorphism, with diabetes (p=0.036), arteritis (trend p=0.022) and hemorrhoids (trend p=0.027).
|
19022366 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The PON1 Q/R polymorphism was found to have significant association with hypertension (p=0.046) and chronic constipation (p=0.028) whereas, the L/M polymorphism, with diabetes (p=0.036), arteritis (trend p=0.022) and hemorrhoids (trend p=0.027).
|
19022366 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with log(e) (ln) of PON1 mass as the dependent variable.
|
19151417 |
2009 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In biopsy specimens, immunohistochemical analysis found increased PON1 expression on the endothelial surface of sclerotic renal arterioles and glomerular capillaries in patients with hypertension or diabetes.
|
19357718 |
2009 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We quantified MDA levels and measured PON1 (paraoxonase/arylesterase) enzymatic activities in subjects suffering from cataract due to aging and diabetes.
|
19439227 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Multiple linear regression analysis showed that LL genotype for PON1 (p < 0.03), high body mass index (BMI) values (p < 0.001) and low HDL-cholesterol levels (p < 0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels.
|
21231776 |
2011 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM.
|
21505009 |
2011 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that PON1 Arg 192 and ACE D alleles act synergistically to increase the risk of CAD in CAD patients and CAD subjects without diabetes from west of Iran, who have high frequency of three-vessel disease.
|
21681430 |
2012 |