|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes.
|
16229851 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
PON activity was significantly decreased in Type 2 DM group compared to the control group.
|
19003935 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with log(e) (ln) of PON1 mass as the dependent variable.
|
19151417 |
2009 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice.
|
30269741 |
2018 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated concentrations of M-HDL particles and elevated levels of HDL-associated PON1 may contribute to long-term protection from the vascular complications of diabetes by pathways that are independent of total cholesterol and HDL cholesterol.
|
31597668 |
2020 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genotyping of 156 Caucasian adolescents with diabetes for seven PON 1 polymorphisms was performed, including that of a novel PON 1 promoter polymorphism A(-1074)G. PON genotypes were related to paraoxonase and arylesterase activities and diabetes complication status.
|
16949520 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In biopsy specimens, immunohistochemical analysis found increased PON1 expression on the endothelial surface of sclerotic renal arterioles and glomerular capillaries in patients with hypertension or diabetes.
|
19357718 |
2009 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences.
|
29981194 |
2018 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have shown that the Q192R polymorphism is a determinant of both PON1 concentration and activity and this association appeared to be enhanced in subjects with diabetes.
|
25477710 |
2014 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In multivariate analysis, PON1 paraoxonase activity was independently of confounding factors associated with diabetes (OR = 0.985; <i>p =</i> 0.024) and premature CHD in family history (OR = 0.983; <i>p =</i> 0.027).
|
30935088 |
2019 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In recent case-control studies serum PON1 concentration and activity were also found to be decreased in coronary heart disease (CHD) independent of the PON1 polymorphism, and in diabetes serum PON1 specific activity decrease is also independent of the PON1 genetic polymorphism.
|
9739487 |
1998 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the presence of metabolic syndrome and diabetes, PON1-192RR and PON2-311CC were associated with an increased risk of SCS and PON1-55MM seems to have lower risk.
|
23053877 |
2013 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver.
|
29773198 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats.
|
29019104 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Independent associations were: 1) PON1 activity negatively with insulin resistance, triglycerides and PON1-55 genotype and positively with PON1-192 genotype; 2) PON1 concentration negatively with Caucasian ethnicity, duration of diabetes and statin use and positively with plasma creatinine and PON1-192 genotype.
|
22846213 |
2012 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It has been reported that human serum paraoxonase (PON1) gene is associated with coronary heart disease (CHD) and diabetes mellitus (DM).
|
16808888 |
2006 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM.
|
21505009 |
2011 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Low PON1 activities have been found in familial hypercholesterolemia (FH) and diabetes mellitus.
|
10978257 |
2000 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Low serum paraoxonase1 (PON1) activity determined by paraoxon substrate is associated with coronary heart disease (CHD), diabetes and systemic lupus erythematosus (SLE) risk.
|
17900266 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Multiple linear regression analysis showed that LL genotype for PON1 (p < 0.03), high body mass index (BMI) values (p < 0.001) and low HDL-cholesterol levels (p < 0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels.
|
21231776 |
2011 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that PON1 Q192R polymorphism was not independently associated with MI but further increased the risk of MI among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.
|
15654230 |
2005 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings thus raise the possibility that PON1 may be of importance in both the genetic and acquired predisposition to premature atherosclerosis and neuropathy in diabetes.
|
9712341 |
1998 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that PON1 may play a role in the onset and development of metabolic alterations in childhood obesity leading to diabetes and cardiovascular disease later in life.
|
24028901 |
2013 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Oxidation has been implicated in the onset of diabetes, and it can be hypothesized that PON1 may have a protective effect on diabetes.
|
18290860 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
The PON1 Q/R polymorphism was found to have significant association with hypertension (p=0.046) and chronic constipation (p=0.028) whereas, the L/M polymorphism, with diabetes (p=0.036), arteritis (trend p=0.022) and hemorrhoids (trend p=0.027).
|
19022366 |
2009 |