Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aims of this study were to estimate the allele frequency of the Pro12Ala polymorphism of PPAR gamma2 gene among native Javanese in Indonesia and to investigate the relationship between this polymorphism and obesity or diabetes.
|
15739197 |
2005 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth: A cross-sectional study according the parental characteristics and newborn's risk for child obesity (the newborns obesity's risk) NOR study.
|
27442659 |
2016 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population.
|
24599720 |
2015 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that obesity is not associated with alteration in PPAR gene expression in abdominal subcutaneous adipose tissue in humans.
|
9231657 |
1997 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that despite the high frequency of the Ala allele at the PPAR-gamma2 gene in our population of Polish men, the Ala12 allele does not appear to improve insulin sensitivity or have an influence on the occurrence of obesity.
|
18777501 |
2009 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) whether the relation of a Pro12Ala polymorphism in PPAR-gamma2 with BMI and long-term weight regulation differ between lean and obese subjects within the same cohort.
|
10440134 |
1999 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity.
|
25502405 |
2015 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the differences in cultivable gut bacteria and peroxisome proliferator-activated receptor γ2 (PPAR-γ2) gene Pro12Ala variation in obese and normal-weight Chinese people.
|
21448362 |
2011 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association between PPAR-gamma2 Prol2Ala polymorphism and glucose metabolism is already present in children and adolescents with obesity who might be at the very beginning of the natural course of type 2 diabetes.
|
21528816 |
2011 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in a relative large-scale study of middle-aged whites we found no evidence of association between the PPARalpha Leu162Val polymorphism and obesity or type 2 diabetes.
|
17129741 |
2007 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia.
|
26673968 |
2015 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that Amerindians do not have association of PPAR-γ2 Ala12 and obesity; the latter was measured by waist circumference values after taken specific Amerindian normal waist parameters.
|
23096090 |
2013 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms have been associated with lipid metabolism and obesity: PPAR-gamma2-Pro115Gln, PPARgamma2-Pro12Ala, beta3AR-Trp64Arg and SR-BI IVS5 C > T. We examined the frequency of these polymorphisms in patients with a BMI > 40 and compared them to individuals with a BMI < 30.
|
12568179 |
2002 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.
|
23545576 |
2013 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that obesity attenuates lung antiviral immunity and hampers host recovery through the modulation of macrophage PPAR-<i>γ</i> expression.
|
31009317 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment.
|
30738174 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
While candidate gene approaches have not been tremendously successful in identifying relevant genetic contributors to obesity, except PPAR , the advent of genome-wide strategies has recently revealed novel and unexpected genetic factors with strong associations with obesity and/or diabetes, i.e.
|
18230892 |
2008 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, whether PPARalpha agonism is an effective form of therapy for obesity-related insulin resistance associated with lipid abnormalities is unclear.
|
18212024 |
2008 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These associations showed that high expression levels of CPT1A, SLC27A2, INSR, FASN, or PPARα may be indicative of a lower risk for the insulin-resistant or dyslipidemic state associated with obesity, whereas low LEPR mRNA levels appear as a marker of high low-density lipoprotein cholesterol, independently of body mass index.
|
22278432 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings establish a central role for HDAC3 in co-ordinating PPAR-regulated lipid oxidation in the intestinal epithelium, and identify intestinal HDAC3 as a potential therapeutic target for preventing obesity and related diseases.
|
31757939 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARα contributes to the CYP2A5 protective effects on fatty liver but it opposes to the protective effects on obesity.
|
29568101 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARalpha deficiency did not influence the growth curves of the obese mice but surprisingly resulted in a severe, age-dependent hyperglycemia.
|
16731822 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor-gamma2 (PPAR(gamma2)) represents the transcriptional master regulator of adipocyte differentiation and therefore has been suggested as candidate gene for the pathogenesis of obesity, type 2 diabetes and related metabolic disorders.
|
11928067 |
2002 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism.
|
25837920 |
2015 |