|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.
|
23545576 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aims of this study were to estimate the allele frequency of the Pro12Ala polymorphism of PPAR gamma2 gene among native Javanese in Indonesia and to investigate the relationship between this polymorphism and obesity or diabetes.
|
15739197 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth: A cross-sectional study according the parental characteristics and newborn's risk for child obesity (the newborns obesity's risk) NOR study.
|
27442659 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population.
|
24599720 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that obesity is not associated with alteration in PPAR gene expression in abdominal subcutaneous adipose tissue in humans.
|
9231657 |
1997 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that obesity attenuates lung antiviral immunity and hampers host recovery through the modulation of macrophage PPAR-<i>γ</i> expression.
|
31009317 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
|
20444420 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
While candidate gene approaches have not been tremendously successful in identifying relevant genetic contributors to obesity, except PPAR , the advent of genome-wide strategies has recently revealed novel and unexpected genetic factors with strong associations with obesity and/or diabetes, i.e.
|
18230892 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, whether PPARalpha agonism is an effective form of therapy for obesity-related insulin resistance associated with lipid abnormalities is unclear.
|
18212024 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5).
|
24814977 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These associations showed that high expression levels of CPT1A, SLC27A2, INSR, FASN, or PPARα may be indicative of a lower risk for the insulin-resistant or dyslipidemic state associated with obesity, whereas low LEPR mRNA levels appear as a marker of high low-density lipoprotein cholesterol, independently of body mass index.
|
22278432 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced DNA methylation is associated with enhanced induction of hepatic FGF21 expression after PPARα activation, which may partly explain the attenuation of diet-induced obesity in adulthood.
|
29434210 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate the differences in the expression of PPARα target genes in human peripheral blood mononuclear cells (PBMCs) and free fatty acids (FFA) in obese and non-obese individuals after 24 h of fasting.
|
25500634 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that despite the high frequency of the Ala allele at the PPAR-gamma2 gene in our population of Polish men, the Ala12 allele does not appear to improve insulin sensitivity or have an influence on the occurrence of obesity.
|
18777501 |
2009 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the enhanced expression of obesity-related proteins (PPAR[Formula: see text], C/EBP[Formula: see text], SREBP-1c, and FAS) in MDI medium-cultivated 3T3-L1 cells was significantly attenuated by the addition of cinnamyl alcohol at 5[Formula: see text][Formula: see text]g/mL and 10[Formula: see text][Formula: see text]g/mL.
|
28490236 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) whether the relation of a Pro12Ala polymorphism in PPAR-gamma2 with BMI and long-term weight regulation differ between lean and obese subjects within the same cohort.
|
10440134 |
1999 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings establish a central role for HDAC3 in co-ordinating PPAR-regulated lipid oxidation in the intestinal epithelium, and identify intestinal HDAC3 as a potential therapeutic target for preventing obesity and related diseases.
|
31757939 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARα contributes to the CYP2A5 protective effects on fatty liver but it opposes to the protective effects on obesity.
|
29568101 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARalpha deficiency did not influence the growth curves of the obese mice but surprisingly resulted in a severe, age-dependent hyperglycemia.
|
16731822 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity.
|
25502405 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor-gamma2 (PPAR(gamma2)) represents the transcriptional master regulator of adipocyte differentiation and therefore has been suggested as candidate gene for the pathogenesis of obesity, type 2 diabetes and related metabolic disorders.
|
11928067 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the differences in cultivable gut bacteria and peroxisome proliferator-activated receptor γ2 (PPAR-γ2) gene Pro12Ala variation in obese and normal-weight Chinese people.
|
21448362 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association between PPAR-gamma2 Prol2Ala polymorphism and glucose metabolism is already present in children and adolescents with obesity who might be at the very beginning of the natural course of type 2 diabetes.
|
21528816 |
2011 |
|
Obesity
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that GSK-3α promotes lipid anabolism through PPARα-Ser280 phosphorylation, which underlies the development of lipotoxic cardiomyopathy in the context of obesity.
|
30745182 |
2019 |