|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet.
|
22102511 |
2011 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Understanding the role natural products play, as well as the mechanisms behind their regulation of PPARγ activity is critical for future research into their therapeutic potential for fighting obesity.
|
27669202 |
2016 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
CTD_human |
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
|
11089532 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs.
|
30420515 |
2018 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
This modification of PPARgamma does not alter its adipogenic capacity, but leads to dysregulation of a large number of genes whose expression is altered in obesity, including a reduction in the expression of the insulin-sensitizing adipokine, adiponectin.
|
20651683 |
2010 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
|
11574398 |
2001 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
This review highlights the roles that PPARgamma play in the regulation of gene expression associated with normal cell physiology as well as the pathophysiology of multiple diseases including obesity, diabetes and cancer.
|
11900961 |
2002 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity.
|
24969838 |
2014 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
|
9753710 |
1998 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR.
|
15860437 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk.
|
12395215 |
2002 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
<i>PPARG-LYPLAL1</i> Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females.
|
27773974 |
2016 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome Proliferator-Activated Receptor Gamma in Obesity and Colorectal Cancer: the Role of Epigenetics.
|
28878369 |
2017 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity.
|
19913841 |
2010 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
|
18657264 |
2008 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Phtalates are thought to contribute to obesity through their binding and activation of PPARγ receptor that in turn results in the upregulation of adipocyte production.
|
27358237 |
2017 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.
|
15725703 |
2005 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
PPARG mRNA expression decreased 32% (P = 0.044) in adipocytes from individuals with obesity.
|
31531958 |
2019 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates adipocyte differentiation and lipid deposition, but its role in lipolysis and dysregulation in obesity is not well defined.
|
22310664 |
2012 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
We identified PPARγ as a potential target of Twist 1 and found variation in the secretion of multiple adipokines, which might indicate a prospective mechanism linking Twist 1 expression with obesity or associated diseases.
|
25128964 |
2014 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we elucidated the molecular mechanisms and transcription factors causing the SHBG down-regulation during obesity development, which involved changes in liver hepatocyte nuclear factor 4α and peroxisome proliferator-activated receptor-γ mRNA and protein levels.
|
26441241 |
2015 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome.
|
21643757 |
2012 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Our results suggest that a novel MG derivative, CBMG may have beneficial applications in the control of obesity through the suppression of PPARγ-induced adipocyte differentiation and lipid accumulation.
|
28625492 |
2017 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
The causes of obesity are multifactorial but may include dysregulation of a family of related genes, such as the peroxisome proliferator activated receptor gamma (PPARgamma).
|
18855061 |
2009 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association.
|
22410809 |
2012 |