|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
<i>PPARG-LYPLAL1</i> Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females.
|
27773974 |
2016 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Obesity can occur as a result of genetic or acquired changes in three main types of biochemical processes, which are the main focus of this review: a)feeding control, which determines the sensations of satiety and hunger through processes that depend on an interplay between internal signals (notably leptin) and environmental factors; b) energy efficiency, in particular the activation of thermogenesis mediated by uncoupling proteins (UCPs) that makes it possible to dissipate part of the energy contained in food as heat instead of accumulating it as fat, and c) adipogenesis, the process by which cells specialised in fat storage (adipocytes) are formed, which is controlled by an interplay of transcription factors, including members of the C/EBP, PPARgamma and ADD families.
|
11079733 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis.
|
26361038 |
2015 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a transcription factor plays an important role in lipid metabolism, glucose homeostasis, insulin sensitivity, obesity, diabetes, foam cell formation and atherogenesis.
|
10690291 |
1999 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women.
|
11916956 |
2002 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia.
|
12406034 |
2002 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma is a crucial molecule in atherogenesis because it is associated with metabolic risk factors such as obesity and diabetes and also plays a key role in subcellular metabolism of arterial wall macrophage foam cells.
|
15284449 |
2004 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma is an important regulator of adiposity in mouse and man, and common variation in the PPARG gene has been associated with birthweight, adult obesity, insulin sensitivity and type 2 diabetes.
|
16007414 |
2005 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) may play an important role in obesity and Type 2 diabetes mellitus (T2DM).
|
16759305 |
2006 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator activated receptor gamma is a ligand-dependent transcription factor with an important role in insulin resistance and obesity.
|
21669017 |
2011 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet.
|
22102511 |
2011 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor γ (PPARγ) ligands are therapeutic agents used in patient with Type 2 diabetes and obesity which have recently been studied for their potential anti-tumor effect.
|
23254958 |
2013 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
PPARγ neddylation essential for adipogenesis is a potential target for treating obesity.
|
26990658 |
2016 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator activated receptor-gamma (PPAR-γ) is implicated in several metabolic syndromes including Diabetic Nephropathy, besides obesity, insulin insensitivity, dislipidemia, inflammation, and hypertension.
|
28539091 |
2018 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome Proliferator-Activated Receptor Gamma in Obesity and Colorectal Cancer: the Role of Epigenetics.
|
28878369 |
2017 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation and is closely linked to the development of obesity.
|
29233982 |
2017 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
PPAR-γ gene polymorphism is associated with and increased the risk of psoriasis and its associated obesity in Egyptian patients.
|
31148857 |
2020 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
PPARG mRNA expression decreased 32% (P = 0.044) in adipocytes from individuals with obesity.
|
31531958 |
2019 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects.
|
9200661 |
1997 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity.
|
19913841 |
2010 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.
|
11248748 |
2001 |