|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects.
|
9200661 |
1997 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Screening for mutations in the entire coding region of the PPAR gamma gene (both gamma 1 and gamma 2 isoforms) was performed with DNA of 26 diabetic Caucasians with or without obesity.
|
9425261 |
1997 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
|
9753710 |
1998 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
The observation that thiazolidinediones enhance skeletal muscle insulin sensitivity in obesity and in patients with non-insulin-dependent diabetes mellitus (NIDDM), by activating PPARgamma, and possibly by inducing its expression, suggests that PPARgamma expression in skeletal muscle plays a key role in determining tissue sensitivity to insulin, and that PPARgamma expression may be decreased in insulin resistant subjects.
|
9449686 |
1998 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Finally peroxisome proliferator activated receptor-gamma (PPAR-gamma) mRNA levels were significantly lower in visceral adipose tissue in subjects with a BMI <30 kg/m2, but not in obese subjects, indicating that relative PPAR-gamma expression is increased in omental fat in obesity.
|
9421381 |
1998 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Our results establish a role for PPARgamma in the regulation of EC gene expression, with important implications for the clinical links between obesity and atherosclerosis.
|
10073956 |
1999 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a transcription factor plays an important role in lipid metabolism, glucose homeostasis, insulin sensitivity, obesity, diabetes, foam cell formation and atherogenesis.
|
10690291 |
1999 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
CTD_human |
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
|
11089532 |
2000 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Obesity can occur as a result of genetic or acquired changes in three main types of biochemical processes, which are the main focus of this review: a)feeding control, which determines the sensations of satiety and hunger through processes that depend on an interplay between internal signals (notably leptin) and environmental factors; b) energy efficiency, in particular the activation of thermogenesis mediated by uncoupling proteins (UCPs) that makes it possible to dissipate part of the energy contained in food as heat instead of accumulating it as fat, and c) adipogenesis, the process by which cells specialised in fat storage (adipocytes) are formed, which is controlled by an interplay of transcription factors, including members of the C/EBP, PPARgamma and ADD families.
|
11079733 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the PPARgamma gene are unlikely to be major contributors to HAIRAN syndrome with obesity.
|
10762291 |
2000 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
This study reveals a hitherto unpredicted role for PPARgamma in high-fat diet-induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPARgamma.
|
11242476 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose.
|
10873398 |
2000 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
|
11574398 |
2001 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
|
11158005 |
2001 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.
|
11248748 |
2001 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
These observations lend genetic evidence consistent with our hypothesis that PPARG serves as a common, low-penetrance susceptibility gene for cancers of several types, especially those epidemiologically associated with obesity and fat intake.
|
11511919 |
2001 |
|
Obesity
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
This review highlights the roles that PPARgamma play in the regulation of gene expression associated with normal cell physiology as well as the pathophysiology of multiple diseases including obesity, diabetes and cancer.
|
11900961 |
2002 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk.
|
12395215 |
2002 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women.
|
11916956 |
2002 |
|
Obesity
|
1.000 |
Biomarker
|
disease |
BEFREE |
Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy.
|
11832353 |
2002 |