Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
A recent report detected association between GPR50, an orphan G protein-coupled receptor, and bipolar disorder (BD) in the Scottish population [29].
|
20371266 |
2010 |
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD).
|
15452587 |
2005 |
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
Biomarker
|
disease |
BEFREE |
GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD).
|
15452587 |
2005 |
Mood Disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
We investigated the relationship of the gene for the X-linked orphan G protein-coupled receptor (GPR50) to childhood-onset mood disorders in a sample of 384 families with 468 affected children and adolescents collected in Hungary.
|
18075476 |
2007 |
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
However, cure of MM is still difficult, and several other targets, for example immunoglobulin kappa chain, SLAM Family Member 7 (SLAMF7), or G-protein coupled receptor family C group 5 member D (GPRC5D), are being tested as targets for CAR T cells.
|
31847470 |
2019 |
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Additional ADCs and bispecific antibodies targeting BCMA and other surface antigens (eg, CD38, CD46, CD48, FcRH5, and G protein-coupled receptor, class C group 5 member D) are moving forward in phase 1 trials and may provide even more options for MM patients.
|
31808859 |
2019 |
Multiple Myeloma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Highly variable levels of GPRC5D (median, 288; quartiles, 17-928) were detected in patients with MM, whereas only low expression was detected in normal tissues (median, 1; quartiles, 1-23).
|
22591013 |
2012 |
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest that GPRC5D is an antigen specific to multiple myeloma and a potential target of TRAB therapy.
|
31270154 |
2019 |
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
GPRC5D(109) is specific for GPRC5D and resulted in MM cell line and primary MM cytotoxicity, cytokine release, and in vivo activity comparable to anti-BCMA CAR T cells.
|
30918115 |
2019 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we report, for the first time, the association of GPRC5D expression and cancer.
|
22591013 |
2012 |
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently.
|
28612367 |
2017 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells.
|
19552806 |
2009 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
|
20818416 |
2011 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
|
20818416 |
2011 |
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently.
|
28612367 |
2017 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
RAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells.
|
19552806 |
2009 |
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we report, for the first time, the association of GPRC5D expression and cancer.
|
22591013 |
2012 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
GPRC5A is an orphan G-protein coupled receptor with an intriguing dual behavior, acting as an oncogene in some cancers and as a tumor suppressor in other cancers.
|
27415424 |
2016 |
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed.
|
22330140 |
2012 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The strong and selective expression of GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies.
|
23510526 |
2013 |
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis.
|
19572147 |
2010 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway.
|
17575113 |
2007 |
MAJOR AFFECTIVE DISORDER 1
|
0.020 |
Biomarker
|
disease |
BEFREE |
GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD).
|
15452587 |
2005 |