Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Murine and cynomolgus cross-reactive CAR T cells did not cause alopecia or other signs of GPRC5D-mediated toxicity in these species.
|
30918115 |
2019 |
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cluster of differentiation 133 (CD133) and leu cine-rich orphan G-protein-coupled receptor 5 (LGR5) are the most putative stem cell markers for colorectal cancer (CRC), and are associated with poor prognosis of patients with CRC.
|
31280219 |
2019 |
Glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The orphan G-protein-coupled receptor (GPCR) GPR158 is expressed in the brain, where it is involved in the osteocalcin effect on cognitive processes, and at the periphery, where it may contribute to glaucoma and cancers.
|
31189666 |
2019 |
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
|
31127149 |
2019 |
Acromegaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
An orphan G-protein-coupled receptor causes human gigantism and/or acromegaly: Molecular biology and clinical correlations.
|
29678281 |
2018 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
G protein-coupled receptor 25 (GPR25) is an orphan G protein-coupled receptor in vertebrates, that has been implicated to be associated with autoimmune diseases and regulate blood pressure in humans.
|
29727602 |
2018 |
Gigantism
|
0.010 |
Biomarker
|
disease |
BEFREE |
An orphan G-protein-coupled receptor causes human gigantism and/or acromegaly: Molecular biology and clinical correlations.
|
29678281 |
2018 |
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we demonstrate Gpr52, an orphan G protein-coupled receptor, as a potential Huntington's disease drug target.
|
29608652 |
2018 |
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases.
|
28425521 |
2017 |
Right Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPR91 is a formerly orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate; however, its role in RVH remains unknown.
|
26824665 |
2016 |
Small cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we searched for GPCRs that were expressed in lung cancer: the mRNA encoding orphan G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
|
22912338 |
2012 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we searched for GPCRs that were expressed in lung cancer: the mRNA encoding orphan G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
|
22912338 |
2012 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we searched for GPCRs that were expressed in lung cancer: the mRNA encoding orphan G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
|
22912338 |
2012 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we searched for GPCRs that were expressed in lung cancer: the mRNA encoding orphan G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
|
22912338 |
2012 |
Monosomy 13q14 syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
High mRNA expression of GPRC5D correlated positively with high plasma cell count in bone marrow (r = 0·64, P < 0·001), high β(2) -microglobulin (r = 0·42, P = 0·003) and poor-risk cytogenetics: deletion 13q14 (rb-1), P = 0·003; and 14q32 translocation t(4;14)(p16;q32), P = 0·029.
|
22591013 |
2012 |
Hypotrichosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We and others recently reported that mutations in the P2RY5 gene, encoding an orphan G protein-coupled receptor, underlie autosomal recessive woolly hair (WH)/hypotrichosis.
|
18803659 |
2009 |
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The orphan G-protein-coupled receptor 37 (GPR37) is a substrate of parkin, and its insoluble aggregates accumulate in brain tissue samples of Parkinson's disease patients, including Lewy bodies and neurites.
|
19218498 |
2009 |
Schizophrenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia.
|
19796684 |
2009 |
Congenital hypotrichia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We and others recently reported that mutations in the P2RY5 gene, encoding an orphan G protein-coupled receptor, underlie autosomal recessive woolly hair (WH)/hypotrichosis.
|
18803659 |
2009 |
POLYMICROGYRIA, BILATERAL FRONTOPARIETAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPR56 is an orphan G protein - coupled receptor, mutations of which have recently been associated with bilateral frontoparietal polymicrogyria, a rare neurologic disease that has implications in brain development.
|
17575113 |
2007 |
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we describe the identification of GPCR56, an orphan G-protein coupled receptor, to be differentially expressed in esophageal squamous cell carcinoma.
|
15916848 |
2006 |
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
GPR56 (also known as TM7XN1) is a newly discovered orphan G-protein-coupled receptor (GPCR) of the secretin family that has a role in the development of neural progenitor cells and has been linked to developmental malformations of the human brain.
|
15674329 |
2005 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
KiSS-1 has been cloned as a human metastasis suppressor gene and an orphan G-protein-coupled receptor (hOT7T175) identified as the endogenous receptor of the KiSS-1 product.
|
12898236 |
2003 |
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains.
|
10802050 |
2000 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains.
|
10802050 |
2000 |