|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we identified several lncRNA-TF-gene triplets (including HOTAIR-MXI1-CD58/PRKCE and HOTAIR-ATF5-NCAM1) that are associated with glioblastoma prognosis.
|
26943771 |
2016 |
|
Agnosia for Pain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein kinase C ε (PKCε) AS-ODN also prevented LDM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected.
|
31209174 |
2019 |
|
Allodynia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
|
11738263 |
2001 |
|
Allodynia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
|
12582831 |
2003 |
|
Allodynia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Hyperalgesic priming is restricted to isolectin B4-positive nociceptors.
|
20457222 |
2010 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes.
|
12198386 |
2002 |
|
Alpha carotene level
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations.
|
28002826 |
2016 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, these data demonstrate that the relationship between Aβ levels and PKCε is markedly altered in AD patients' brains and skin fibroblasts, reflecting a loss of protective effect of PKCε against toxic Aβ accumulation.
|
25125477 |
2015 |
|
Amelogenesis imperfecta nephrocalcinosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we firstly demonstrated that Iso can elicit protective effects against ERS injury in N2a cells and these effects are mediated at least in part via PKCε pathway.
|
28715866 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of leukotriene modifier response in asthma.
|
26031901 |
2016 |
|
B-Cell Lymphomas
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Moreover, PKCε physically interacts with Stat3, and knockdown of PKCε expression attenuated Stat3Ser727 phosphorylation and B-cell lymphoma-extra large (Bcl-xL) expression in the two human glioma cell lines.
|
24888992 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNAi silencing of Sp1 and STAT1 in breast cancer cells reduced PKCϵ mRNA and protein expression, as well as PRKCE promoter activity.
|
24825907 |
2014 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In summary, CGH combined with a dense mapped resource of BACs and large-scale sequencing has led directly to the definition of PKCepsilon as a previously unmapped candidate gene involved in thyroid tumorigenesis.
|
9683604 |
1998 |
|
Cardiomegaly
|
0.200 |
Biomarker
|
phenotype |
RGD |
Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts.
|
15792354 |
2005 |
|
Cardiomyopathies
|
0.300 |
Biomarker
|
group |
CTD_human |
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.
|
15242976 |
2004 |
|
Cardiomyopathies, Primary
|
0.300 |
Biomarker
|
group |
CTD_human |
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.
|
15242976 |
2004 |
|
Cardiomyopathy, Dilated
|
0.010 |
Biomarker
|
group |
BEFREE |
Employing LC-MS/MS, we determined the presence of phosphorylation sites at S5/S6 in cTnI from wild type mouse hearts as well as in hearts of mice chronically expressing active protein kinase C-ε (PKCε) and exhibiting severe dilated cardiomyopathy (DCM).
|
22940544 |
2013 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Employing LC-MS/MS, we determined the presence of phosphorylation sites at S5/S6 in cTnI from wild type mouse hearts as well as in hearts of mice chronically expressing active protein kinase C-ε (PKCε) and exhibiting severe dilated cardiomyopathy (DCM).
|
22940544 |
2013 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein kinase C-epsilon (epsilonPKC) induces neurite outgrowth in neuroblastoma cells but molecular mechanism of the epsilonPKC-induced neurite outgrowth is not fully understood.
|
17697049 |
2007 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we identified several lncRNA-TF-gene triplets (including HOTAIR-MXI1-CD58/PRKCE and HOTAIR-ATF5-NCAM1) that are associated with glioblastoma prognosis.
|
26943771 |
2016 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein kinase C-epsilon (epsilonPKC) induces neurite outgrowth in neuroblastoma cells but molecular mechanism of the epsilonPKC-induced neurite outgrowth is not fully understood.
|
17697049 |
2007 |
|
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Phosphorylation of the vanilloid receptor (TRPV1) by protein kinase C epsilon (PKCepsilon) plays an important role in the development of chronic pain.
|
18973552 |
2008 |