|
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C ε (PKCε) AS-ODN also prevented LDM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected.
|
31209174 |
2019 |
|
Myocardial Infarction
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We therefore studied platelet PKCε expression from 24 patients with myocardial infarction, 24 patients with stable coronary artery disease and 24 healthy subjects.
|
23071564 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39).
|
23931760 |
2013 |
|
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia.
|
30679921 |
2019 |
|
Mechanical Allodynia
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia.
|
30679921 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
BEFREE |
These results identify an expanded set of proteins through which PKCε may drive high-fat diet-induced hepatic insulin resistance that may direct new therapeutic approaches for T2D.
|
30181290 |
2018 |
|
Coronary Artery Disease
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Indeed, platelets from myocardial infarction patients expressed PKCε with a significant frequency as compared to both stable coronary artery disease and healthy subjects.
|
23071564 |
2012 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Clone formation, wound healing, and Borden assays showed that down-regulating PKCε by RNA interference resulted in inhibition of the growth, migration, and invasion of clear cell RCC cell line 769P and, more importantly, sensitized cells to chemotherapeutic drugs as indicated by enhanced activity of caspase-3 in PKCε siRNA-transfected cells.
|
21955404 |
2011 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The results indicate that PKCvarepsilon-mediated Stat3Ser727 phosphorylation is essential for constitutive activation of Stat3 and cell invasion in various human cancers.
|
20228845 |
2010 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The aim of the study is to investigate whether knockdown of PKCε expression by RNA interference (RNAi) could affect the growth, apoptosis and invasion of human glioma cells, and the involvement of the signal transducer and activator of transcription 3 (Stat3) signaling pathway in these effects.
|
24888992 |
2015 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C ε (PKCε) has emerged as an oncogenic protein kinase and plays important roles in cancer cell survival, proliferation, and invasion.
|
30209539 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C ε (PKCε) has emerged as an oncogenic kinase and plays important roles in cell survival, mitogenesis and invasion.
|
22955280 |
2012 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, PKCε appears to become specifically engaged in a programme of controls that are required to support cell-cycle progression in transformed cells, advocating for PKCε as a potential cancer therapeutic target.<b>Implications:</b> The close relationship between PKCε dependency for mitotic spindle organization and the nonfunctionality of the TOPO2A-dependent G<sub>2</sub> checkpoint, a hallmark of transformed cells, strongly suggests PKCε as a therapeutic target in cancer.<i>Mol Cancer Res; 16(1); 3-15.©2017 AACR</i>.
|
29021232 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
This surprising capacity indicates PKCε as a novel predictive marker protein in molecular cancer therapy with EGFR tyrosine kinase inhibitors.
|
21964064 |
2012 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Suppression of the PKCε-encoding gene achieved through the antisense cDNA, suppression of PKCε with RNAi and inhibition achieved with translocation-inhibitory peptides may provide novel treatment strategies for cancer.
|
21441608 |
2011 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Protein kinase C ε (PKCε) has emerged as an oncogenic protein kinase and plays important roles in cancer cell survival, proliferation, and invasion.
|
30209539 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Suppression of the PKCε-encoding gene achieved through the antisense cDNA, suppression of PKCε with RNAi and inhibition achieved with translocation-inhibitory peptides may provide novel treatment strategies for cancer.
|
21441608 |
2011 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, PKCε appears to become specifically engaged in a programme of controls that are required to support cell-cycle progression in transformed cells, advocating for PKCε as a potential cancer therapeutic target.<b>Implications:</b> The close relationship between PKCε dependency for mitotic spindle organization and the nonfunctionality of the TOPO2A-dependent G<sub>2</sub> checkpoint, a hallmark of transformed cells, strongly suggests PKCε as a therapeutic target in cancer.<i>Mol Cancer Res; 16(1); 3-15.©2017 AACR</i>.
|
29021232 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
This surprising capacity indicates PKCε as a novel predictive marker protein in molecular cancer therapy with EGFR tyrosine kinase inhibitors.
|
21964064 |
2012 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Protein kinase C ε (PKCε) has emerged as an oncogenic protein kinase and plays important roles in cancer cell survival, proliferation, and invasion.
|
30209539 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
By immunohistochemistry, we found that the expression of PKCε was up-regulated in RCCs and was associated with tumor Fuhrman grade and T stage in clear cell RCCs.
|
21955404 |
2011 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our data showed that knockdown of PKCε expression inhibited proliferation, induced apoptosis and decreased invasiveness of human glioma cell lines U251 and U87, as well as suppressed the growth of U87 cell-derived tumors in nude mice.
|
24888992 |
2015 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings offer the first genetic evidence of the role of PKCε in PCa development and metastasis.
|
21406403 |
2011 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our studies identified a molecular link between PKCε and NF-κB that controls key responses implicated in prostate cancer progression.
|
22955280 |
2012 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our studies identified a molecular link between PKCε and NF-κB that controls key responses implicated in prostate cancer progression.
|
22955280 |
2012 |