|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, we found an association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer.
|
21373201 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Performing multivariate logistic regression analysis, a significant association between PRKCI overexpression and presence of lymph node metastasis was found, which was independent of T-stage of the primary tumors (P = 0.004).
|
17990328 |
2008 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Also, cell polarity-related genes PARD3, PRKCI and DLGAP3, and autophagy-related genes ULK1 and ULK2 genes are considered to play crucial roles in tumorigenesis.
|
28844109 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C iota (PKCι) has been shown to play an important role in tumorigenesis of many cancers.
|
27481515 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Over expression of Stathmin1 (STMN1), activation-induced cytidine deaminase (AID) and protein kinase C iota (PKCi) proteins participate in the regulation of carcinogenesis.
|
25075050 |
2014 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C iota (PKCι) has been shown to have an important role in tumorigenesis of many cancers, but little is known about its role in rhabdomyosarcoma.
|
22349825 |
2013 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Here, it is demonstrated that PKCι maintains a tumor-initiating cell (TIC) phenotype that drives ovarian tumorigenesis.
|
24174471 |
2013 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Similarly, poor outcomes have recently been observed in cancer patients with overexpression of protein kinase C iota (PKCiota), an atypical protein kinase C that is activated by oncogenic Ras protein and is required for K-Ras-induced transformation and colonic carcinogenesis in vivo.
|
18794128 |
2008 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Our data demonstrate that PKCiota is required for oncogenic Ras- and carcinogen-mediated colon carcinogenesis in vivo and define a procarcinogenic signaling axis consisting of Ras, PKCiota, and Rac1.
|
15024028 |
2004 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem-like cell (GSC) survival.
|
27299852 |
2016 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Previously, we have shown that protein kinase C iota (PKCι) depletion induces cellular senescence in glioblastoma cells in the absence of a detectable DNA damage response.
|
26208522 |
2015 |
|
Glioblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
This phenomenon was not restricted to breast cancer cells, as it was also seen in glioblastoma cells in which PKCι is activated by loss of PTEN.
|
22120720 |
2012 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The focus of this research was to investigate the role of protein kinase C-iota (PKC-ι) in regulation of Bad, a pro-apoptotic BH3-only molecule of the Bcl-2 family in glioblastoma.
|
21419810 |
2011 |
|
Glioblastoma
|
0.050 |
Biomarker
|
disease |
LHGDN |
Regulation of glioblastoma cell invasion by PKC iota and RhoB.
|
18212741 |
2008 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Previous in-vitro studies have shown that 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1s), a PKC-ι specific inhibitor, is effective against some cancer cell lines by decreasing cell growth and inducing apoptosis.
|
30204596 |
2019 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545.
|
31409777 |
2019 |
|
Glioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma.
|
30204596 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
And clinical data suggested that the distribution of circ-PRKCI rose with the depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, indicating that circ-PRKCI may affect the survival and prognosis of patients with HCC by regulating <i>E2E7</i>.
|
31086464 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Previous in-vitro studies have shown that 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1s), a PKC-ι specific inhibitor, is effective against some cancer cell lines by decreasing cell growth and inducing apoptosis.
|
30204596 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Of these, PRKCI is one of the most frequently amplified and overexpressed genes and its expression induced cancer cell proliferation and migration/invasion <i>in vitro</i> as well as tumor growth <i>in vivo</i>.
|
29228547 |
2017 |
|
ovarian neoplasm
|
0.040 |
Biomarker
|
disease |
BEFREE |
The PRKCI-YAP1 regulation of the tumor immunity provides a therapeutic strategy for highly lethal ovarian cancer.
|
28698296 |
2017 |
|
ovarian neoplasm
|
0.040 |
Biomarker
|
disease |
BEFREE |
Atypical protein kinase Cι (PKCι) is an oncogene in lung and ovarian cancer.
|
27321186 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Of these, PRKCI is one of the most frequently amplified and overexpressed genes and its expression induced cancer cell proliferation and migration/invasion <i>in vitro</i> as well as tumor growth <i>in vivo</i>.
|
29228547 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Of these, PRKCI is one of the most frequently amplified and overexpressed genes and its expression induced cancer cell proliferation and migration/invasion <i>in vitro</i> as well as tumor growth <i>in vivo</i>.
|
29228547 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Meanwhile, IHC stain revealed that PKCι was positively correlated with clinical pathologic variables such as tumor size, tumor grade, and tumor invasion, as well as ki67.
|
27481515 |
2016 |