|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Mitogen-activated protein kinase 8 (MAP3K8) is direct target of miR-144-3p, while the expression levels of MAP3K8 were inversely correlated with the expression levels of miR-144-3p in RCC tissues.
|
27717821 |
2016 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma.
|
24626183 |
2014 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment.
|
28344324 |
2017 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
In conclusions, RASSF10 functions as a tumor suppressor by cooperating with GSTP1 to deregulate JNK/c-Jun/AP-1 pathway in GC.
|
26279301 |
2016 |
|
Malignant neoplasm of stomach
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activity of MMP9 and MMP2 via JNK and ERK.
|
26291058 |
2015 |
|
Malignant neoplasm of stomach
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Among examined genes in the Fas signaling pathway, MAP2K4, FAF1, MAPK8, CASP10, CASP8, CFLAR, MAP2K1, CAP8AP2, PAK2 and IKBKB were associated with risk of GC (nominal p < 0.05), and FAF1 and MAPK8 were significantly associated with risk of both GCA and GNCA (nominal p< 0.05).
|
23921907 |
2014 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
BEFREE |
Importantly, activated Pak1 elicited phosphorylation of the ERK and JNK-dependent pathway in gastric cancer cell lines.
|
22293972 |
2012 |
|
Malignant neoplasm of stomach
|
0.350 |
Biomarker
|
disease |
CTD_human |
We investigated whether JNK1, a major JNK isozyme, is involved in chemically induced gastric cancer development.
|
18593901 |
2008 |
|
Hyperalgesia
|
0.330 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, inhibitors of neuronal nitric oxide synthase (nNOS) activation and guanylate cyclase (GC) inhibitor could not only inhibit the expression of pJNK in the Vc, but also effectively alleviate masseter hyperalgesia induced by restraint stress.
|
31798413 |
2019 |
|
Hyperalgesia
|
0.330 |
PosttranslationalModification
|
phenotype |
BEFREE |
Our findings may partially confirm the role of β-arrestin 2 and PKC rearrangements, Erk1/2 and JNK phosphorylation in crack-induced hyperalgesia and provide potential therapeutic targets to attenuate crack-induced hyperalgesia.
|
30641110 |
2019 |
|
Hyperalgesia
|
0.330 |
Biomarker
|
phenotype |
BEFREE |
Together, our data suggest that central ERK is involved in the analgesic and hyperalgesic effects of morphine while JNK, p38, and CREB are involved in the morphine-induced delayed hyperalgesia.
|
31616243 |
2019 |
|
Hyperalgesia
|
0.330 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
BEFREE |
Sab<sup>ΔHep</sup> mice or Jnk1+2<sup>ΔHep</sup> mice did not develop ALF following administration of VPA and APAP.
|
31029706 |
2019 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
BEFREE |
We found in human and murine samples of ibuprofen-induced acute liver failure that JNK phosphorylation was increased in the cytoplasm of hepatocytes and other non-liver parenchymal cells (non-LPCs) compared with healthy tissue.
|
30264435 |
2019 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Ligustilide Relieves Complete Freund's Adjuvant-induced Mechanical Hyperalgesia through Inhibiting the Activation of Spinal c-Jun N-terminal Kinase/c-Jun Pathway in Rats.
|
29200725 |
2019 |
|
Dermatitis, Atopic
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
This research has shown upregulated Fas, FasL, p-ERK, p-p38, and p-JNK expression along with increased cytokine secretion (IL-1β, IL-4, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IL-31 and TNFα) by keratinocytes derived from the skin of patients with the AD when compared with healthy control.
|
30286163 |
2018 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
BEFREE |
Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
|
29498756 |
2018 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
It was also showed that both the JNK inhibitor SP600125 and the NF-κB inhibitor PDTC significantly attenuated thermal hyperalgesia and mechanical allodynia in CCI rats.
|
27895138 |
2017 |
|
Mechanical Allodynia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
CTD_human |
JNK1-/- mice showed less ear thickening and infiltration of eosinophils and mast cells in AD-like lesions than did WT mice when treated with MC903.
|
24046278 |
2013 |
|
Liver Failure, Acute
|
0.320 |
Biomarker
|
disease |
CTD_human |
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
|
17185352 |
2007 |
|
Mental Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The link between NASH and depression raised the role of JNK activation through increase expression of JNK1.
|
27916420 |
2017 |
|
Depressive disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The link between NASH and depression raised the role of JNK activation through increase expression of JNK1.
|
27916420 |
2017 |
|
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
It was also showed that both the JNK inhibitor SP600125 and the NF-κB inhibitor PDTC significantly attenuated thermal hyperalgesia and mechanical allodynia in CCI rats.
|
27895138 |
2017 |