|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study.
|
28060188 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Further adjusting age, gender and BMI as confounders found PROX1 rs340874 was associated with type 2 diabetes (p = 0.0391).
|
21103350 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
HHEX and PROX1 are genetic loci associated with diabetes mellitus type 2.
|
27684496 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
Biomarker
|
disease |
CTD_human |
We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes.
|
20081858 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We identified a significant association of a SNP of FADS1 and a SNP near PROX1 with T2D in a Japanese population.
|
22992776 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
The Type 2 Diabetes Susceptibility PROX1 Gene Variants Are Associated with Postprandial Plasma Metabolites Profile in Non-Diabetic Men.
|
31010169 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
AlteredExpression
|
disease |
BEFREE |
All together, we propose that reduced expression of PROX1 by cis-regulatory variants results in altered β-cell insulin secretion and thereby confers susceptibility to type 2 diabetes.
|
23274905 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
|
29358691 |
2018 |
|
Obesity
|
0.210 |
Biomarker
|
disease |
MGD |
Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
|
16170315 |
2005 |
|
Obesity
|
0.210 |
GeneticVariation
|
disease |
BEFREE |
Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians.
|
23818313 |
2013 |
|
Obesity
|
0.210 |
Biomarker
|
disease |
MGD |
Prox1 function is crucial for mouse lens-fibre elongation.
|
10080188 |
1999 |
|
Obesity
|
0.210 |
Biomarker
|
disease |
MGD |
Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.
|
12692551 |
2003 |
|
Obesity
|
0.210 |
Biomarker
|
disease |
MGD |
Prox1 function is required for the development of the murine lymphatic system.
|
10499794 |
1999 |
|
Status Epilepticus
|
0.200 |
Biomarker
|
disease |
RGD |
Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat.
|
17042797 |
2006 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, we linked long-term proliferative capacity in a patient-derived model of CRC to a lowly abundant PROX1-positive cancer stem cell subtype.
|
31451731 |
2019 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, our data suggests that PROX1 and Notch suppress each other and that PROX1-mediated suppression of Notch mediates its stem cell function in colorectal cancer.<b>Significance:</b> These findings address the role of the PROX1 homeobox factor as a downstream effector of Wnt/β-catenin singling in colorectal cancer stem cells and show that PROX1 inhibits the Notch pathway and helps to enforce the stem cell phenotype and inhibit differentiation.<i></i>.
|
30154153 |
2018 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, Prox1 is essential for the expansion of the stem cell pool in intestinal adenomas and CRC without being critical for the normal functions of the gut.
|
25242330 |
2014 |
|
Colorectal Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
These data identify PROX1 as a key regulator of the transcriptional network contributing to metastases outgrowth in colorectal cancer.
|
25242332 |
2014 |
|
Colorectal Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer.
|
30396930 |
2018 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Prospero-related homeobox 1 (PROX1) is a downstream target of the Wnt/β-catenin pathway in human colorectal cancer and elevated PROX1 expression promotes malignant progression.
|
25684142 |
2015 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
However, we show here that PROX1 promotes dysplasia in colonic adenomas and colorectal cancer progression.
|
18455124 |
2008 |