|
Adenoid Cystic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High Expression of Prospero-Related Homeobox-1 (PROX1) Is Associated With Poor Prognosis in Patients With Salivary Adenoid Cystic Carcinoma.
|
29406257 |
2018 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PROX1 expression marks the transition from benign colon adenoma to carcinoma in situ, and its loss inhibits growth of human colorectal tumor xenografts and intestinal adenomas in Apc(min/+) mice, while its transgenic overexpression promotes colorectal tumorigenesis.
|
18455124 |
2008 |
|
Adult Angiosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, strong positive nuclear staining for MYC and prox-1 was seen in cases of postradiation cutaneous angiosarcoma, whereas control cases and cases of atypical vascular proliferation after radiotherapy were negative for MYC, and stained only focally positive for prox-1 in a number of cases.
|
21909081 |
2012 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings highlight the prognostic value of PROX1 and its role as a regulator of glioblastoma gene expression subtypes, intratumoral heterogeneity, proliferation, and cell-cycle control.<b>Significance:</b> These findings demonstrate the role and prognostic value of PROX1 in glioblastomas; low PROX1 levels correlate with a mesenchymal gene expression subtype and shorter survival in glioblastoma tumors.<i></i>.
|
30135192 |
2018 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
An NF‑κB reporter assay demonstrated that PROX1‑overexpressing glioblastoma cells had significantly greater NF‑κB‑dependent reporter activities compared with empty vector‑transfected controls.
|
28035380 |
2017 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status.
|
27626492 |
2016 |
|
Adult-onset obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Also, surviving Prox1 heterozygous mice have shown abnormal lymphatic patterning and adult-onset obesity, indicating that accumulation of adipocytes could be closely linked with lymphatic function.
|
23378608 |
2013 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Prox1 expression is transiently re-activated in acinar cells undergoing dedifferentiation and acinar-to-ductal metaplastic conversion.
|
26992918 |
2016 |
|
Anaplastic astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, high expression of PROX1 protein predicted shorter survival in the group of patients with IDH-mutant anaplastic astrocytomas and secondary glioblastomas.
|
27626492 |
2016 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.
|
25176150 |
2014 |
|
Astrocytoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study we explored the correlation between PROX1 expression and patient survival in high-grade astrocytomas.
|
27626492 |
2016 |
|
Astrocytoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Prospero homeobox protein 1 (PROX1) is highly expressed in high-grade malignant astrocytic gliomas.
|
28035380 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.
|
25176150 |
2014 |
|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, PROX1 has been ascribed suppressive as well as oncogenic roles in several human cancers, including brain tumors.
|
27626492 |
2016 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Long non-coding RNA LINC00968 reduces cell proliferation and migration and angiogenesis in breast cancer through up-regulation of PROX1 by reducing hsa-miR-423-5p.
|
31213129 |
2019 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Among survivors who received 10 or higher gray breast radiation exposure, a locus on 1q41 was associated with subsequent breast cancer risk (rs4342822, nearest gene PROX1 , risk allele frequency in control subjects [RAF controls ] = 0.46, hazard ratio = 1.92, 95% confidence interval = 1.49 to 2.44, P = 7.09 × 10 -9 ).
|
29059430 |
2017 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Additionally, treatment of breast cancer cell lines with demethylating agents could reactivate PROX1 transcription.
|
17415710 |
2007 |
|
Carbohydrate intolerance
|
0.010 |
Biomarker
|
disease |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
PROX1 expression marks the transition from benign colon adenoma to carcinoma in situ, and its loss inhibits growth of human colorectal tumor xenografts and intestinal adenomas in Apc(min/+) mice, while its transgenic overexpression promotes colorectal tumorigenesis.
|
18455124 |
2008 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that PROX1 functions as a tumor suppressor gene in oral carcinogenesis.
|
25526434 |
2014 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study was to gain more knowledge on the PROX1 function in thyroid tumorigenesis.
|
31060342 |
2019 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Together these data suggest that Prox1 negatively regulates neuroblastoma carcinogenesis through suppression of Cdc25A and induction of p27-Kip1 to counteract CyclinE1 overexpression and block cell cycle progression.
|
22508481 |
2013 |