PROX1, prospero homeobox 1, 5629

N. diseases: 114; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.200 Biomarker group MGD
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 function is crucial for mouse lens-fibre elongation. 10080188 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 function is required for the development of the murine lymphatic system. 10499794 1999
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.020 AlteredExpression disease BEFREE By combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry, we demonstrate that lymphatics are abundant in cirrhosis. 11719431 2001
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.010 AlteredExpression disease BEFREE By combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry, we demonstrate that lymphatics are abundant in cirrhosis. 11719431 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. 12692551 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE These findings indicate that the profile of the PROX1 gene corresponds to that of a candidate tumor-suppressor gene. 12874782 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 AlteredExpression disease BEFREE There was a significant increase in the degree of Prox-1 and 5'-nucleotidase expression in colon cancer tissue. 12851706 2003
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 AlteredExpression disease BEFREE There was a significant increase in the degree of Prox-1 and 5'-nucleotidase expression in colon cancer tissue. 12851706 2003
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.010 PosttranslationalModification group BEFREE Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. 12874782 2003
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker disease MGD Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. 16170315 2005
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.200 Biomarker disease RGD Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat. 17042797 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Subsequently, we also showed that low expression of Prox1 in tumors was closely associated with a poor prognosis. 17062673 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE In mice, xenografts of tumor cells with tetracycline-induced wt-Prox1 formed tumor masses significantly more slowly than control tumors, whereas mutated Prox1 had no effect. 17217617 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE Its growth-conferring abilities were assessed by transiently overexpressing Prox1 in HCC cell lines and by knocking down its expression by RNA interference. 17062673 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease LHGDN Its growth-conferring abilities were assessed by transiently overexpressing Prox1 in HCC cell lines and by knocking down its expression by RNA interference. 17062673 2006
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 GeneticVariation phenotype BEFREE These findings may point to a pivotal role of the RNA mutation of prox1 gene in the pathogenesis of human cancer progression. 17217617 2006
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE To address the possibility that Prox1 may be involved in the tumorigenesis of hepatocellular carcinoma (HCC), human clinical samples were analyzed. 17062673 2006
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.010 Biomarker disease LHGDN Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. 16525637 2006
CUI: C0036572
Disease: Seizures
Seizures 		0.010 Biomarker phenotype BEFREE Prox-1 immunohistochemistry and pulse-chase bromodeoxyuridine labeling showed that progenitors migrate aberrantly to the hilus and molecular layer after prolonged seizures and differentiate into ectopic DGCs in rat. 16261566 2006
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 Biomarker disease BEFREE Furthermore, loss of Prox1 function may be a driving force behind pancreatic carcinoma progression. 16525637 2006
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 AlteredExpression disease BEFREE Expression of Prox1 was reduced in pancreatic cancers, and the extent of reduction correlated with progression of tumor differentiation. 17217617 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.380 Biomarker phenotype CTD_human Secondary, we analysed 38 brain metastases of primary breast carcinomas and detected a significantly reduced expression of PROX1 compared to normal breast tissue (p < 0.001) and primary breast carcinomas (p < 0.05), respectively. 17415710 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE We have recently reported a novel finding that a candidate tumor suppressor gene prox1 suffered adenosine-to-inosine (A-to-I) RNA mutation without genomic mutation in a subset of human cancer cells and lost its function. 17533110 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Seventeen paraffin-embedded specimens of carcinomas of the bilary system were subjected to loss-of-heterozygosity (LOH) and microsatellite instability analyses, methylation-specific polymerase-chain reaction (MSP) and immunohistochemical detection of PROX1 protein in tumor sections. 17069925 2007