|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic RAP and CP.
|
26110235 |
2015 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
It has been recently shown that a loss-of-function variant, c.571G>A (p.G191R), in the anionic trypsinogen (PRSS2) gene protects against chronic pancreatitis in European populations.
|
19052022 |
2009 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
However mutations in cationic and anionic trypsinogen gene do not play an important role in causing CP in Asia Pacific region.
|
21323990 |
2011 |
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
CTD_human |
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
|
16699518 |
2006 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4).
|
25253127 |
2015 |
|
Pancreatitis, Chronic
|
0.490 |
AlteredExpression
|
disease |
LHGDN |
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
|
16699518 |
2006 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study (GWAS) identified association with variants in X-linked CLDN2 and MORC4, and PRSS1-PRSS2 loci with chronic pancreatitis (CP) in North American patients of European ancestry.
|
26820620 |
2016 |
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
CTD_human |
Hereditary chronic pancreatitis.
|
18206817 |
2008 |
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.
|
16699518 |
2006 |
|
Pancreatitis, Alcoholic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
|
28754779 |
2018 |
|
Pancreatitis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
These individuals and 100 patients with pHPT without pancreatitis were analysed for CTRC (p.R254W and p.K247_R254del) and PRSS2 (p.G191R) mutations using melting curve analysis and DNA sequencing or PCR and gel electrophoresis (in case of p.K247_R254del CTRC).
|
20625975 |
2011 |
|
Pancreatitis
|
0.140 |
Biomarker
|
disease |
HPO |
|
|
|
|
Pancreatitis
|
0.140 |
Biomarker
|
disease |
LHGDN |
Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation.
|
18461367 |
2008 |
|
Pancreatitis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
|
23143602 |
2012 |
|
Pancreatitis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
In contrast, no pancreatitis-associated mutations have been found in the anionic trypsinogen gene (PRSS2), suggesting that this isoform might play a relatively unimportant role in pancreatitis.
|
14695529 |
2004 |
|
Pancreatic Pseudocyst
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Pancreatic disorders (not diabetes)
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders.
|
19052022 |
2009 |
|
Pancreatic Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Taken together, the observations indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions.
|
12709065 |
2003 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Among these proteins, three (SYCN, REG1B, and PRSS2) were previously reported as circulating candidate biomarkers of pancreatic cancer.
|
31538697 |
2019 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hyperexpression of the PRSS2 gene and hypermethylation of ELA3B gene promoter were associated with PC, raising the possibility of their application as new biomarkers in PC diagnosis and screening.
|
20428826 |
2010 |
|
Pancreatic calcification
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Nonorganic psychosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of Parkinson's disease cases alone indicated that serpin-A5 and serpin-A13, and trypsin-2 expression in midbrain and cerebral cortex was different in cases with a high incidence of L-DOPA-induced dyskinesia and psychosis compared to those with low levels of these treatment-induced side effects.
|
25982926 |
2015 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.
|
18062964 |
2008 |