|
Acute on chronic pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
|
26110235 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma.
|
16395704 |
2006 |
|
Nonorganic psychosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of Parkinson's disease cases alone indicated that serpin-A5 and serpin-A13, and trypsin-2 expression in midbrain and cerebral cortex was different in cases with a high incidence of L-DOPA-induced dyskinesia and psychosis compared to those with low levels of these treatment-induced side effects.
|
25982926 |
2015 |
|
Tongue Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms.
|
22909050 |
2012 |
|
Epithelial ovarian cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tissue expression of TATI and an elevated preoperative serum concentration of trypsin-2-API are strong independent prognostic factors in advanced epithelial ovarian cancer.
|
15269150 |
2004 |
|
Lewy Body Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The number of microglia that expressed trypsin-2 increased in primary motor cortex of incidental Lewy body disease cases.
|
25982926 |
2015 |
|
Pancreatic disorders (not diabetes)
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders.
|
19052022 |
2009 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The effects of invasion were analyzed using trypsin-2 over-expressing human tongue squamous cell carcinoma cells (Try2-HSC-3) in vitro and in vivo.
|
22909050 |
2012 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.
|
18062964 |
2008 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (OR<sub>homozygous</sub> = 1.19, 95% CI 1.02-1.38, p = 0.023).
|
28913878 |
2018 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As anionic trypsinogen (PRSS2) G191R protects against chronic pancreatitis in Europeans, we investigated whether this variant protects from TCP in Indians.
|
19077465 |
2009 |
|
Collagenopathy, type 2 alpha 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II.
|
16192646 |
2005 |
|
Tropical infectious disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we characterize the structural and proteolytic attributes of serine protease 2 (SmSP2) from Schistosoma mansoni, one of the major species responsible for the tropical infectious disease, schistosomiasis.
|
29677188 |
2018 |
|
Patent ductus arteriosus - persisting type
|
0.010 |
Biomarker
|
disease |
BEFREE |
Five decreased proteins (platelet factor 4, fibrinogen, von Willebrand factor, collagen, and mannose binding lectin-associated serine protease-2) and one increased protein (fibronectin) may increase the risk of patent ductus arteriosus.
|
30480800 |
2019 |
|
Infection caused by Human T-lymphotropic virus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
|
23861212 |
2013 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tissue expression of TATI and an elevated preoperative serum concentration of trypsin-2-API are strong independent prognostic factors in advanced epithelial ovarian cancer.
|
15269150 |
2004 |
|
Hereditary pancreatitis
|
0.630 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
CTD_human |
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
|
16699518 |
2006 |
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
CTD_human |
Hereditary chronic pancreatitis.
|
18206817 |
2008 |
|
Autosomal Dominant Hereditary Pancreatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Pancreatitis, Alcoholic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
|
28754779 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
|
15776435 |
2005 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis.
|
18362849 |
2008 |
|
Pancreatitis, Chronic
|
0.490 |
AlteredExpression
|
disease |
LHGDN |
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
|
16699518 |
2006 |