Malignant neoplasm of prostate
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Genomic Southern blot analysis using methylation sensitive restriction endonucleases was employed to examine the prostasin gene promoter region in prostate cancer cell lines.
|
14991861 |
2004 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Mechanistic study showed that tumor inhibition of PRSS8 may be associated with proliferation- and epithelial mesenchymal transition - related proteins in ESCC cells.
|
27081034 |
2016 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that a specific 9-mer amino acid epitope (designated CAP-1) of the human "self" tumor-associated carcinoembryonic antigen can be used to stimulate CD8+ T cells from peripheral blood mononuclear cells of carcinoma patients vaccinated with pox vector-based carcinoembryonic antigen vaccines.
|
12738714 |
2003 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Recently, many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role in cancer development.
|
27983922 |
2017 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Our data demonstrate that PRSS8 may serve as a tumour suppressor in HCC progression, and represent a valuable prognostic marker and potential therapeutic target for HCC.
|
27915333 |
2016 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of PRSS8 inhibited tumor growth in vitro and in vivo.
|
27983914 |
2017 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Moreover, an epitope derived from CEA, designated CAP1 (YLSGANLNL), has been proposed as naturally processed and presented by tumors in the human leukocyte antigen (HLA)-A*0201 context.
|
20386466 |
2010 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In conclusion, PRSS8 is a novel tumor suppressor that plays critical roles in the suppression of colorectal carcinogenesis and metastasis.
|
30115975 |
2019 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
PRSS8 expression profiles stratified by OVC tumor stage-, grade- and subtype were generated using cDNA samples from 159 OVC samples.
|
27036110 |
2016 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Protease serine 8 (PRSS8), a trypsin-like serine peptidase, has been shown to function as a tumour suppressor in various malignancies.
|
27915333 |
2016 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Recently, many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role in cancer development.
|
27983922 |
2017 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Increased PRSS8 expression inhibited cancer cell growth and metastasis in nude mice and inhibited cancer cell migration, invasion, colony formation and tumor sphere formation in vitro, but decreased PRSS8 expression facilitated malignancies in vivo and in vitro.
|
30115975 |
2019 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
De-methylation agent decitabine was able to restore PRSS8 expression, leading to the inhibition of cancer cell proliferation, motility, migration and cell cycle arrest.
|
27081034 |
2016 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
PRSS8 upregulation inhibited glioma cell proliferation, migration, and invasion.
|
27983922 |
2017 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Increased PRSS8 expression inhibited cancer cell growth and metastasis in nude mice and inhibited cancer cell migration, invasion, colony formation and tumor sphere formation in vitro, but decreased PRSS8 expression facilitated malignancies in vivo and in vitro.
|
30115975 |
2019 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, ectopic expression of PRSS8 inhibited the migration and invasion of NSCLC cells.
|
27983914 |
2017 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In contrast, silencing PRSS8 expression in non-metastatic HepG2 cells significantly enhanced cell growth and invasion.
|
27915333 |
2016 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our study showed that PRSS8 plays an important role in the growth and metastasis of NSCLC.
|
27983914 |
2017 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, PRSS8 is a novel tumor suppressor that plays critical roles in the suppression of colorectal carcinogenesis and metastasis.
|
30115975 |
2019 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
|
27915333 |
2016 |
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Recently, many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role in cancer development.
|
27983922 |
2017 |
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
De-methylation agent decitabine was able to restore PRSS8 expression, leading to the inhibition of cancer cell proliferation, motility, migration and cell cycle arrest.
|
27081034 |
2016 |
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Increased PRSS8 expression inhibited cancer cell growth and metastasis in nude mice and inhibited cancer cell migration, invasion, colony formation and tumor sphere formation in vitro, but decreased PRSS8 expression facilitated malignancies in vivo and in vitro.
|
30115975 |
2019 |
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats.
|
12626364 |
2003 |
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the prostasin gene may be implicated in the development of hypertension in youths..
|
18583984 |
2008 |