|
Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that genetic deficiency of the Prss8 gene caused spontaneous colitis and an inflamed rectum at an early age and caused intestinal tumors at a late age, which were linked to increased intestinal cell proliferation and migration but decreased cell differentiation.
|
30115975 |
2019 |
|
Intestinal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We found that genetic deficiency of the Prss8 gene caused spontaneous colitis and an inflamed rectum at an early age and caused intestinal tumors at a late age, which were linked to increased intestinal cell proliferation and migration but decreased cell differentiation.
|
30115975 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, PRSS8 is a novel tumor suppressor that plays critical roles in the suppression of colorectal carcinogenesis and metastasis.
|
30115975 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study showed that PRSS8 plays an important role in the growth and metastasis of NSCLC.
|
27983914 |
2017 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, PRSS8 may act as a novel therapeutic target for glioma.
|
27983922 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The PRSS8 overexpression signature was specific for OVC and urinary bladder cancer among 18 human cancer types.
|
27036110 |
2016 |
|
Cholera
|
0.010 |
Biomarker
|
disease |
BEFREE |
CAP-1 displayed a broad antimicrobial spectrum against the indicator bacteria and fungus, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Candida albicans, especially some marine-derived microorganisms such as Vibrio vulnificus, Vibrio alginolyticus, Vibrio parahaemolyticus, Vibrio cholera, and Vibrio anguillarum, but showed little impact on tumor cells and normal human cells.
|
26529191 |
2016 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Interestingly, ESCC stromal expression of PRSS8 was significantly correlated with stromal lymphocyte infiltration and cancer progression.
|
27081034 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
|
27081034 |
2016 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The PRSS8 overexpression signature was specific for OVC and urinary bladder cancer among 18 human cancer types.
|
27036110 |
2016 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low intratumoral PRSS8 expression was significantly correlated with poor overall survival (OS) in patients with HCC (P = 0.001).
|
27915333 |
2016 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
|
27915333 |
2016 |
|
Beta thalassemia trait
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, five of the 10 iron-deficient βTT cases carried the silent CAP+1 (A>C) β-thalassemia allele accounting for the borderline HbA2%.
|
24754744 |
2015 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify a novel physiological role for PRSS8 in the liver and provide new insight into the development of diabetes resulting from HFD or metabolic endotoxemia.
|
24614850 |
2014 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
These results identify a novel physiological role for PRSS8 in the liver and provide new insight into the development of diabetes resulting from HFD or metabolic endotoxemia.
|
24614850 |
2014 |
|
Endotoxemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results identify a novel physiological role for PRSS8 in the liver and provide new insight into the development of diabetes resulting from HFD or metabolic endotoxemia.
|
24614850 |
2014 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We used Western blotting to determine the expression of matriptase and prostasin proteins in a panel of breast cancer cell lines and immunohistochemistry to assess the expression in serial sections from breast cancer tissue arrays.
|
21678412 |
2012 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Influenza virus RNA polymerase (RdRp) PB2 is the cap-1 binding subunit and determines host range and pathogenicity.
|
22146492 |
2012 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We used Western blotting to determine the expression of matriptase and prostasin proteins in a panel of breast cancer cell lines and immunohistochemistry to assess the expression in serial sections from breast cancer tissue arrays.
|
21678412 |
2012 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
|
21933610 |
2011 |
|
Transitional cell carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
|
19849847 |
2009 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A panel of 16 urothelial and TCC cell lines were evaluated for prostasin and E-cadherin expression by western blot and quantitative PCR, and for prostasin gene promoter region CpG methylation by methylation-specific PCR (MSP).
|
19849847 |
2009 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
|
17145811 |
2006 |
|
Oxyphilic Adenoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
|
17145811 |
2006 |
|
Prostate carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Genomic Southern blot analysis using methylation sensitive restriction endonucleases was employed to examine the prostasin gene promoter region in prostate cancer cell lines.
|
14991861 |
2004 |