PRSS8, serine protease 8, 5652

N. diseases: 54; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239849
Disease: Harlequin Fetus
Harlequin Fetus 		0.200 Biomarker disease MGD
CUI: C0598226
Disease: Harlequin type ichthyosis
Harlequin type ichthyosis 		0.200 Biomarker disease MGD
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE Influenza virus RNA polymerase (RdRp) PB2 is the cap-1 binding subunit and determines host range and pathogenicity. 22146492 2012
CUI: C0008354
Disease: Cholera
Cholera 		0.010 Biomarker disease BEFREE CAP-1 displayed a broad antimicrobial spectrum against the indicator bacteria and fungus, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Candida albicans, especially some marine-derived microorganisms such as Vibrio vulnificus, Vibrio alginolyticus, Vibrio parahaemolyticus, Vibrio cholera, and Vibrio anguillarum, but showed little impact on tumor cells and normal human cells. 26529191 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE PRSS8 expression profiles stratified by OVC tumor stage-, grade- and subtype were generated using cDNA samples from 159 OVC samples. 27036110 2016
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 PosttranslationalModification disease BEFREE PRSS8 methylation and its significance in esophageal squamous cell carcinoma. 27081034 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 Biomarker phenotype BEFREE PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma. 27915333 2016
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 Biomarker group BEFREE PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma. 27915333 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE Protease serine 8 (PRSS8), a trypsin-like serine peptidase, has been shown to function as a tumour suppressor in various malignancies. 27915333 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 AlteredExpression phenotype BEFREE PRSS8 upregulation inhibited glioma cell proliferation, migration, and invasion. 27983922 2017
CUI: C1861305
Disease: TARSAL-CARPAL COALITION SYNDROME
TARSAL-CARPAL COALITION SYNDROME 		0.010 AlteredExpression disease BEFREE A panel of 16 urothelial and TCC cell lines were evaluated for prostasin and E-cadherin expression by western blot and quantitative PCR, and for prostasin gene promoter region CpG methylation by methylation-specific PCR (MSP). 19849847 2009
CUI: C0020428
Disease: Hyperaldosteronism
Hyperaldosteronism 		0.010 Biomarker disease BEFREE Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. 12626364 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 Biomarker group BEFREE Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. 12626364 2003
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.310 Biomarker disease CTD_human Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. 16541421 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.300 Biomarker group CTD_human Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. 16541421 2006
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.010 GeneticVariation disease BEFREE Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population. 21933610 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE De-methylation agent decitabine was able to restore PRSS8 expression, leading to the inhibition of cancer cell proliferation, motility, migration and cell cycle arrest. 27081034 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 AlteredExpression group BEFREE De-methylation agent decitabine was able to restore PRSS8 expression, leading to the inhibition of cancer cell proliferation, motility, migration and cell cycle arrest. 27081034 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE Ectopic expression of PRSS8 inhibited tumor growth in vitro and in vivo. 27983914 2017
CUI: C0011999
Disease: Diastematomyelia
Diastematomyelia 		0.300 Therapeutic disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.300 Therapeutic group CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
CUI: C0027806
Disease: Neurenteric Cyst
Neurenteric Cyst 		0.300 Therapeutic disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
CUI: C0032045
Disease: Placenta Disorders
Placenta Disorders 		0.300 Therapeutic group CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
CUI: C0080218
Disease: Tethered Cord Syndrome
Tethered Cord Syndrome 		0.300 Therapeutic disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
CUI: C0152234
Disease: Iniencephaly
Iniencephaly 		0.300 Therapeutic disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014