|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The CTNNBIP1 function as tumor suppressor gene or oncogene in different types of cancer is controversial.
|
30076728 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Our studies also identified several down-regulated candidate tumor suppressor genes (CTNNBIP1, CASP9, PRDM2, and SFN) in 1p36.33-p35.3 that may be of clinical significance in high-grade tumors.
|
22505352 |
2012 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Our results imply that i) genetic alteration of the ICAT gene does not play an important role in abnormal accumulation of CTNNB1 that would cause up-regulation of the Wnt signalling pathway, ii) mechanisms other than genetic alteration may have inactivated ICAT function, or iii) gene(s) on 1p36 other than ICAT may be the responsible tumor suppressor gene for tumors that show frequent 1p36-LOH.
|
15492799 |
2004 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Real-time RT-PCR showed markedly reduced ICAT transcript levels (<or=20% relative to normal skin and benign melanocytic nevi) in 28/36 malignant melanomas (78%), including 13/14 tumors with LOH on 1p36.
|
12124804 |
2002 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
These results suggest that Wnt signaling is critical for the growth of colorectal tumors and some hepatocellular carcinomas and that expression of ICAT or drugs which mimic its effects may be useful in the treatment of these tumors.
|
12036951 |
2002 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Also, in agreement with the above, the ectopic expression of CTNNBIP1 inhibits the migration of lung cancer cells, whereas the CTNNBIP1 knockdown increases cancer cell migration.
|
31766223 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The CTNNBIP1 function as tumor suppressor gene or oncogene in different types of cancer is controversial.
|
30076728 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The ICAT gene was mapped to chromosome 1p36.1-p36.2, which is implicated in the pathogenesis of various types of cancers.
|
12417602 |
2002 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The CTNNBIP1 function as tumor suppressor gene or oncogene in different types of cancer is controversial.
|
30076728 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Also, in agreement with the above, the ectopic expression of CTNNBIP1 inhibits the migration of lung cancer cells, whereas the CTNNBIP1 knockdown increases cancer cell migration.
|
31766223 |
2019 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using ICAT as a tool to disengage β-catenin-mediated APC-Axin interaction, we demonstrate that Wnt quickly inhibits the direct interaction between APC and Axin.
|
30197296 |
2018 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Frequent methylation (44-45%) than deletion (20-32%) with overall alterations of 52-55% was observed in MCC/CTNNBIP1 in the BC samples.
|
27208794 |
2016 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We demonstrate that miR-603 regulates glioma development via its WIF1 and CTNNBIP1 targets, which suggests that miR-603 may be a promising candidate for therapeutic applications in glioma treatment.
|
25681036 |
2015 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
It promotes TGF-β1-induced oncogenesis by suppressing CTNNBIP1 in glioma.
|
26317904 |
2015 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further study demonstrated that miR-424-5p reversed resistance to anoikis and EMT of HCCs by directly targeting ICAT and further maintaining the E-cadherin/β-catanin complex on the cellular membrance.
|
25175916 |
2014 |
|
Adenomatous Polyposis Coli
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication.
|
18844223 |
2009 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
|
18500270 |
2008 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Several proteomics technologies including 2D-PAGE, 2D-DIGE, ICAT, SELDI-TOF, MudPIT and protein arrays have been used to uncover molecular mechanisms associated with breast carcinoma at the global level, and a number of these technologies, particularly the SELDI-TOF hold promise as a proteomic approach that can be applied at the bedside for discovering protein patterns that distinguish disease and disease-free states with high sensitivity and specificity.
|
15652811 |
2005 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Cases exhibiting ICAT overexpression showed a significantly higher incidence of well-differentiated adenocarcinoma and positive lymphatic permeation.
|
12417602 |
2002 |
|
Colorectal Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These results suggest that Wnt signaling is critical for the growth of colorectal tumors and some hepatocellular carcinomas and that expression of ICAT or drugs which mimic its effects may be useful in the treatment of these tumors.
|
12036951 |
2002 |
|
Colorectal Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
However, no mutations in ICAT were detected among 128 colorectal tumors.
|
12417602 |
2002 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that Wnt signaling is critical for the growth of colorectal tumors and some hepatocellular carcinomas and that expression of ICAT or drugs which mimic its effects may be useful in the treatment of these tumors.
|
12036951 |
2002 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Interestingly, EBV and CMV infections modulate CTNNBIP1 expression.
|
30076728 |
2019 |