|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The associations of PTEN polymorphisms and their interactions with HBV mutations with HCC risk were assessed using multivariate logistic regression analysis.
|
25881591 |
2015 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data provide the first evidence that the PTEN/MMAC1 gene is mutated in a subset of HCC samples.
|
10340391 |
1999 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only the mutation in PTEN has a common Catalogue of Somatic Mutations in Cancer ID in the CLC and coexistent HCC-like area, and is related to the kinase-RAS module.
|
31261448 |
2019 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumor suppression gene PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important antagonist of the phosphoinositide-3-kinase (PI3K)/adenosine triphosphate-dependent tyrosine kinase (Akt) pathway, is also commonly lost or mutated in HCC.
|
20430845 |
2010 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) is one of the most commonly lost or mutated genes in a variety of human cancers, including HCC.
|
20428814 |
2010 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
LOH at the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) region (D10S215, AFMa086wg9 and D10S541) was found in 8 of the 18 (44.4%) HCCs.
|
17786367 |
2007 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms.
|
19082655 |
2009 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Taken together, we found that FR5 effectively inhibits proliferation and induces apoptosis of HCC cells through coordinated inhibition of YAP in the Hippo pathway and AKT in the PI3K-PTEN-mTOR pathway, and suggest FR5 as a potential therapy for HCC.
|
29299170 |
2017 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, Kras activation in combination with heterozygous PTEN deletion induced mixed carcinomas of liver (both ICC and hepatocellular carcinoma, HCC), whereas Kras activation alone did not induce biliary tract neoplasm.
|
29452147 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of endogenous RET was found to be upregulated by miR-218, and siRNA-induced RET downregulation resulted in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) upregulation and reversal of the inhibitory effect of miR-218 upregulation on HCC proliferation.
|
25374061 |
2015 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Down-regulation of LncRNA NR027113 inhibits cell proliferation and metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular carcinoma.
|
30468465 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MiR-328 is involved in the development of HCC via regulating PTEN, which might provide a new target for HCC diagnosis and therapy.
|
30338800 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the potential role of PTEN/MMAC1 gene in the genesis of hepatocellular carcinomas, we examined 96 tumors for allelic loss on 10q and also for subtle mutations anywhere within the coding region of PTEN/MMAC1 gene.
|
10363579 |
1999 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
|
25909289 |
2015 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the expression status of SALL4, HDAC1, and HDAC2 and their relationship with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) by immunohistochemical analysis of the posthepatectomy specimens of 135 patients with hepatocellular carcinoma who were treated at our hospital.
|
28411180 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC).
|
31801250 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
While AKT2 is the major isoform downstream of activated phosphoinositide 3-kinase and loss of phosphatase and tensin homolog-induced HCC, the precise function of AKT1 in hepatocarcinogenesis is largely unknown.
|
31062368 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Alterations in this pathway, as well as in TP53 and the cell cycle machinery, and in the PI3K/Akt/mTor axis (the latter activated in the presence of PTEN loss), as well as aberrant angiogenesis and epigenetic anomalies, appear to be major events in HCC.
|
28854942 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, signal transducer and activator of transcription 1 and phosphatase and tensin homolog were associated with early growth response protein 1 signaling in non-tumor lesions, which potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC.
|
23485556 |
2013 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, HBx interrupted the balance between apoptosis and proliferation, which contributed to the development of hepatocellular carcinoma, was also related to the interaction of miR-181a and PTEN.
|
28053323 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Aberrant expression of miR-19a-3p stimulated HCC cell metastasis, and phosphatase and tensin homolog (PTEN) was shown to be a direct target of miR-19a-3p. miR-19a-3p-mediated HCC metastasis was reversed by restoration of PTEN or could be imitated by silencing of PTEN.
|
30021351 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation.
|
25617127 |
2015 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cox multi-factor analysis showed that tumor differentiation (P = 0.006), vascular invasion (P = 0.028), TNM stage (P = 0.005), pAkt (P = 0.021), PTEN (P = 0.003), p27 (P = 0.018) and pS6 (P = 0.002) were independent prognosis factors for HCC.
|
19301157 |
2010 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, authors introduced new integration between gene therapy and nanotechnology in the form of PTEN and TRAIL-loaded ZNPs that proved potential to be used in gene therapy for the treatment of HCC.
|
28140697 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The combined detection of PTEN and hTERT may provide critical clinical evidence for the diagnosis and biological behavior of HCC.
|
25613699 |
2015 |