|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression of miR-367 and PTEN are significantly inverse correlated in 35 HCC patients.
|
26772880 |
2016 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It was also be found that ONTD increase the PPAR-γ activity, reduce the phosphorylation of Akt and increase phosphatase and tensin homologue (PTEN) protein expression in hepatocellular carcinoma (HCC) Bel-7402 cells, and these were associated with the inhibition of cells proliferation.
|
28834734 |
2017 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that miR-128-3p overexpression sensitized HCC to sorafenib-induced apoptosis via PTEN/PI3K/Akt signaling pathway by regulating DJ-1 expression.
|
30402839 |
2018 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mechanism leading to steatosis and its progression toward fibrosis and hepatocellular carcinoma.
|
21465511 |
2011 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that dietary unsaturated fatty acids promote hepatoma progression by reducing the expression of the tumor suppressor PTEN.
|
19398230 |
2009 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PTEN expression is down-regulated in HCC cell lines probably due to loss of activity of PTEN promoter.
|
16052674 |
2005 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This review provides an overview of the current knowledge on pathological dysregulations of PTEN expression/activity in the liver with obesity and the metabolic syndrome, and the role of this enzyme in the development of non-alcoholic fatty liver disease and hepatocellular carcinoma.
|
20460918 |
2010 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of endogenous RET was found to be upregulated by miR-218, and siRNA-induced RET downregulation resulted in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) upregulation and reversal of the inhibitory effect of miR-218 upregulation on HCC proliferation.
|
25374061 |
2015 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The associations of PTEN polymorphisms and their interactions with HBV mutations with HCC risk were assessed using multivariate logistic regression analysis.
|
25881591 |
2015 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data provide the first evidence that the PTEN/MMAC1 gene is mutated in a subset of HCC samples.
|
10340391 |
1999 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only the mutation in PTEN has a common Catalogue of Somatic Mutations in Cancer ID in the CLC and coexistent HCC-like area, and is related to the kinase-RAS module.
|
31261448 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Down-regulation of LncRNA NR027113 inhibits cell proliferation and metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular carcinoma.
|
30468465 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MiR-328 is involved in the development of HCC via regulating PTEN, which might provide a new target for HCC diagnosis and therapy.
|
30338800 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the potential role of PTEN/MMAC1 gene in the genesis of hepatocellular carcinomas, we examined 96 tumors for allelic loss on 10q and also for subtle mutations anywhere within the coding region of PTEN/MMAC1 gene.
|
10363579 |
1999 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Spearman correlation analysis revealed that the expression profiles of ZHX2 and PTEN were positively correlated in HCC tissues (r=0.258, P=0.031).
|
30784286 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
|
25909289 |
2015 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the expression status of SALL4, HDAC1, and HDAC2 and their relationship with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) by immunohistochemical analysis of the posthepatectomy specimens of 135 patients with hepatocellular carcinoma who were treated at our hospital.
|
28411180 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC).
|
31801250 |
2019 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumor suppression gene PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important antagonist of the phosphoinositide-3-kinase (PI3K)/adenosine triphosphate-dependent tyrosine kinase (Akt) pathway, is also commonly lost or mutated in HCC.
|
20430845 |
2010 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
While AKT2 is the major isoform downstream of activated phosphoinositide 3-kinase and loss of phosphatase and tensin homolog-induced HCC, the precise function of AKT1 in hepatocarcinogenesis is largely unknown.
|
31062368 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Alterations in this pathway, as well as in TP53 and the cell cycle machinery, and in the PI3K/Akt/mTor axis (the latter activated in the presence of PTEN loss), as well as aberrant angiogenesis and epigenetic anomalies, appear to be major events in HCC.
|
28854942 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, signal transducer and activator of transcription 1 and phosphatase and tensin homolog were associated with early growth response protein 1 signaling in non-tumor lesions, which potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC.
|
23485556 |
2013 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation through down-regulating PTEN.
|
29487004 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, HBx interrupted the balance between apoptosis and proliferation, which contributed to the development of hepatocellular carcinoma, was also related to the interaction of miR-181a and PTEN.
|
28053323 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Aberrant expression of miR-19a-3p stimulated HCC cell metastasis, and phosphatase and tensin homolog (PTEN) was shown to be a direct target of miR-19a-3p. miR-19a-3p-mediated HCC metastasis was reversed by restoration of PTEN or could be imitated by silencing of PTEN.
|
30021351 |
2018 |