|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
And then, we found there is a negative relationship between the expression of miR-205 and PTEN mRNA in lung cancer by analyzed.
|
25973003 |
2015 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.
|
24292675 |
2014 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The positive expression of PTEN protein in the lung carcinoma tissues was significantly lower than that in the normal lung tissues (P = 0.013), while the level of miR-494 expression was negatively correlated with PTEN expression (r = -0.577, P < 0.01).
|
25861022 |
2015 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the molecular mechanism of EMT induced by PTEN inactivation is not clear in lung cancer.
|
30885348 |
2019 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with these findings, we observed increased PTEN phosphorylation and reduced nuclear PTEN levels in lung cancer patient samples establishing phosphorylation as a bona fide inactivation mechanism for PTEN in lung cancer.
|
29108454 |
2018 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We identified PTEN as miR-130b's major target and inversely correlated with miR-130b expression in LC.
|
29653464 |
2018 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation or inhibition of PRMT5 markedly reduced Akt phosphorylation at Thr308 and Ser473, whereas the expression of PTEN and mTOR phosphorylation was unchanged, indicating that PRMT5 was an important upstream regulator of Akt and induced lung cancer cell proliferation.
|
30461193 |
2019 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells.
|
29876362 |
2018 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.
|
23274758 |
2013 |
|
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system.
|
26832408 |
2016 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The effect of DNA methylation on PTEN expression was evaluated by treatment of lung cancer cell lines with 5-aza-2'-deoxycytidine (5AZA-CdR).
|
25638724 |
2015 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of PTEN function has been detected frequently in different forms of cancers, such as breast, prostate and lung cancer, gastric and colon cancer, skin cancer, as well as endometrial carcinoma.
|
25773992 |
2015 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other driver biomarkers in lung cancer (point mutations and rearrangements in specific genes including Her2, BRAF, NUT, MET, ROS1, DDR2, FGFR1, KRAS, and PTEN) might potentially provide additional information for clinical decision making.
|
24420742 |
2014 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased frequency of IgG heavy chain marker Glm(2) and of HLA-B8 in Lambert-Eaton myasthenic syndrome with and without associated lung carcinoma.
|
2993207 |
1985 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that NEDD4-1 plays a critical role in the development of NSCLC and provides novel insight on the mechanisms that contribute to inactivate PTEN in lung cancer.
|
20889565 |
2010 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The presence of PTEN expression may define a subset of patients with lung cancer appropriate for investigational therapeutic strategies.
|
27333149 |
2016 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, it was strongly indicated that activation of the PI3K/AKT/NFkB pathway by PTEN inactivation results in augmented invasiveness in lung cancer cells and lipid phosphatase activity of PTEN plays a key role in this process.
|
21333374 |
2011 |
|
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear.
|
29271375 |
2018 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear.
|
31266968 |
2019 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using single stranded conformation polymorphism (SSCP) analysis, we screened the PTEN/MMAC1 open reading frame of 53 lung cancer cell line cDNAs for point mutations and found that 3/35 SCLCs and 3/18 NSCLCs contained homozygous amino acid sequence altering mutations.
|
9794233 |
1998 |
|
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTEN protein loss is a frequent event in lung cancer, but genetic alterations are not equally detected.
|
31404976 |
2019 |
|
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
LOH of the PTEN/MMAC1 locus was common in each histologic type of primary lung cancer.
|
10470842 |
1999 |
|
Carcinoma of lung
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Carcinoma of lung
|
0.400 |
GenomicAlterations
|
disease |
CGI |
|
|
|